专利号:US-4940797-A 优先权日:1989-03-23 标题:Process for synthesis of FK-506 C10-C18 intermediates 发明人:JONES TODD K; MILLS SANDER G; DESMOND RICHARD 权利人:MERCK & CO INC 摘要:A process is described for the improved synthesis of the optically pure C 10 -C 18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
专利号:EP-1397373-B1 优先权日:2001-06-07 标 题 :Improved synthesis of allofuranose 发明人:KOCH TROELS; HANSEN HENRIK FRYDENLUND 权利人:SANTARIS PHARMA AS 摘要:The present invention provides a novel strategy for the synthesis of allofuranose using glucofuranose as starting material in a one-pot reaction. The novel finding is that it is possible to carry out the oxidation of 1,2: 5,6-di-O-isopropylidene- alpha -D-glucofuranose with DMSO/acetic anhydride and a reduction reaction in one pot obtaining high yields of recrystallised and analytical pure 1,2:5,6-di-O-isopropylidene- alpha -D-allofuranose.
专利号:US-2004127584-A1 优先权日:2002-12-31 标题 :Chemical vapor deposition synthesis of polymerization catalyst composition 发明人:KALLENBACH LYLE R 权利人:PHILLIPS PETROLEUM CO 摘要:A catalyst composition and a process of using a catalyst composition for preparing high molecular weight hydrocarbons, such as polymethylene, from a fluid containing hydrogen and carbon monoxide are disclosed. The catalyst composition contains ruthenium and a support component. The ruthenium is initially present as ruthenium tetraoxide provided by contacting a ruthenium component and an oxidizing agent to provide the ruthenium tetraoxide that is deposited under a depositing condition on, in, or with the support component.
专利号:US-9309165-B2 优先权日:2012-12-19 标 题 :6-chloro-3-(phenyl-d5)-inden-1-one and use thereof 发明人:JACOBSEN MIKKEL FOG; BRANDES SEBASTIAN 权利人:LUNDBECK & CO AS H 摘要:The present invention discloses the compound 6-chloro-3-(phenyl-d 5 )-inden-1-one (I) and routes of synthesis to obtain (I). In a further aspect the present invention discloses the use of (I) for the synthesis of (S)-6-chloro-3-(phenyl-d 5 )-indan-1-one.
专利号:WO-2014029013-A1 优先权日:2012-08-22 标题:Method for producing silver(i) orthoperiodates 发明人:NADWORNY PATRICIA L; PROSPERI-PORTA GRAEME; UNRAU KEVIN R 权利人:INNOVOTECH INC 摘要:The present invention relates to the synthesis of silver(I) orthoperiodates, preferably Ag 5 IO 6 . The synthesis process comprises mixing in an aqueous solution a hydroxide, a periodate, and a source of single valency silver ions; and allowing the silver(I) orthoperiodate to form.
专利号:US-5155228-A 优先权日:1989-03-23 标 题:FK-506 C10-C18 process intermediates 发明人:JONES TODD K; MILLS SANDER G; DESMOND RICHARD 权利人:MERCK & CO INC 摘要:A process is described for the improved synthesis of the optically pure C 10 -C 18 fragment of the macrolide structure of the immunosuppressant FK-506. This compound is also useful as an intermediate for preparing FK-506 derivatives.
摘要:Singh, F. V., Science of Synthesis Knowledge Updates, (2021) 1, 208. 摘要:Li, J. J., Science of Synthesis: Knowledge Updates, (2025) 2. 参考文献:10.1007/bf01718254 摘要:Anchlan D, Ludwig S, Nymadawa P, Mendsaikhan J, Scholtissek C. Previous H1N1 influenza A viruses circulating in the Mongolian population. Arch Virol. 1996;141(8):1553–69. doi: 10.1007/bf01718254. 参考文献:10.2116/analsci.22.825 摘要:Abdel-Shafi AA. Spectrophotometric determination of manganese by using redox reaction of tris(2,2'-bipyridine)osmium(II) with Mn7+. Anal Sci. 2006 Jun;22(6):825–8. doi: 10.2116/analsci.22.825.