CAS: 85326-06-3; 2-Amino-9-((2R,5S)-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-1H-Purin-6(9H)-One

该化合物是一种核分子模拟,主要用于研究应用,在DNA合成中作为链式抑制剂,主要用于研究应用,其结构缺乏3'hycroxil组,防止进一步结合核分子酸,使其对研究DNA复制机制和测序技术具有价值. ddG在分子生物学中特别有用,因为它能够阻止聚合酶活动,协助分析核酸序列.该化合物在实验环境中具有高度的特性和可靠性,确保一致的结果.在标准实验室条件下,其稳定性进一步提高了其作为研究工具的效用. ddG通常用于昆虫学和病毒学研究,有助于遗传学和抗病毒研究的进步.

结构式图片

相似化合物

961-07-9 207121-55-9 312693-72-4

物理性质

MSDS等安全信息

上下游产品

CAS号85326-13-2 N-(9-(5-(hydrox... | CAS号64350-24-9 N2-异丁酰基鸟苷一水合物 | CAS号89494-39-3 2'-TBDMS-N2-异丁酰基腺苷 | CAS号118-00-3 鸟苷 | CAS号177779-53-2 2-amino-9-((2R,... | CAS号119794-40-0 N2-isobutyryl-2... | CAS号119794-39-7 5'-O-(tert-buty... | CAS号119794-38-6 5'-O-(tert-buty... | CAS号119794-50-2 5'-O-(tert-buty... | CAS号119794-37-5 5'-O-(tert-buty... | CAS号73-40-5 鸟嘌呤

合成工艺路线路线简述

  • 122970-35-8 = 85326-06-3
    反应条件:1.1 Catalysts: Adenosine Deaminase Solvents: Water
    标题:Enzymic Synthesis Of 2',3'-Dideoxyguanosine
    作者:Nair,Vasu; Et Al
    参考文献:Synlett 日期:1991 卷标:(10) 页码:753-4]

    177779-53-2 = 85326-06-3
    反应条件:1.1 Reagents: Pyridine,Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran
    标题:Synthesis And 1H And 13C Nmr Spectral Characteristics Of 8-Bromo-2',3'-Dideoxyguanosine And 8-Bromo-2',3'-Dideoxyinosine
    作者:Zeidler,Joanna; Et Al
    参考文献:Nucleosides & Nucleotides 日期:1996 卷标:15(5) 页码:1077-1095]

    107550-73-2 = 85326-06-3
    反应条件:1.1 Catalysts: Adenosine Deaminase Solvents: Water; 48 H,Ph 7,37 °C
    标题:Arthrobacter Oxydans As A Biocatalyst For Purine Deamination
    作者:Medici,Rosario; Et Al
    参考文献:Fems Microbiology Letters 日期:2008 卷标:289(1) 页码:20-26]

    = 85326-06-3
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 12 H,0.4 Mpa,Rt2.1 Reagents: Methylamine Solvents: Methanol; 5 H,Rt
    标题:Synthesis And Anti-Hiv Activity Of A Series Of 6-Modified 2',3'-Dideoxyguanosine And 2',3'-Didehydro-2',3'-Dideoxyguanosine Analogs
    作者:Xie,Lujia; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2013 卷标:31(9) 页码:1207-1218]

    6160-65-2 + 72560-68-0 = 85326-06-3
    反应条件:1.1 Solvents: Dimethylformamide1.2 -2.1 Reagents: Azobisisobutyronitrile,Dibutyltin Oxide Solvents: 1,4-Dioxane2.2 Reagents: Ammonium Hydroxide Solvents: Methanol
    标题:A Novel And Efficient Preparation Of 2',3'-Dideoxynucleosides
    作者:Prisbe,Ernest J.; Et Al
    参考文献:Synthetic Communications 日期:1985 卷标:15(5) 页码:401-9]

    6160-65-2 + 98056-54-3 = 85326-06-3
    反应条件:1.1 Solvents: Dimethylformamide1.2 -2.1 -
    标题:A Novel And Efficient Preparation Of 2',3'-Dideoxynucleosides
    作者:Prisbe,Ernest J.; Et Al
    参考文献:Synthetic Communications 日期:1985 卷标:15(5) 页码:401-9]

    85326-13-2 = 85326-06-3
    反应条件:1.1 Reagents: Ammonia Solvents: Methanol
    标题:General Syntheses Of 2',3'-Dideoxynucleosides And 2',3'-Didehydro-2',3'-Dideoxynucleosides
    作者:Chu,C. K.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(9) 页码:2217-25]

    119794-40-0 = 85326-06-3
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Rt
    标题:Crystal Structure Of Metacavir Ethanol Solvent Compound
    作者:Liu,Cai-Lian; Et Al
    参考文献:Huaxue Shiji 日期:2013 卷标:35(1) 页码:52-54]

    = 85326-06-3
    反应条件:1.1 Reagents: Methylamine Solvents: Methanol; 5 H,Rt
    标题:Synthesis And Anti-Hiv Activity Of A Series Of 6-Modified 2',3'-Dideoxyguanosine And 2',3'-Didehydro-2',3'-Dideoxyguanosine Analogs
    作者:Xie,Lujia; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2013 卷标:31(9) 页码:1207-1218]

    107550-73-2 = 85326-06-3
    反应条件:1.1 Catalysts: Adenosine Deaminase; 48 H
    标题:Coupled Biocatalysts Applied To The Synthesis Of Nucleosides
    作者:Medici,Rosario; Et Al
    参考文献:Nucleic Acids Symposium Series 日期:2008 卷标:52(1) 页码:541-542]

    98056-51-0 = 85326-06-3
    反应条件:1.1 Reagents: Azobisisobutyronitrile,Dibutyltin Oxide Solvents: 1,4-Dioxane1.2 Reagents: Ammonium Hydroxide Solvents: Methanol
    标题:A Novel And Efficient Preparation Of 2',3'-Dideoxynucleosides
    作者:Prisbe,Ernest J.; Et Al
    参考文献:Synthetic Communications 日期:1985 卷标:15(5) 页码:401-9]

    98056-55-4 = 85326-06-3 [标题:Reaction Conditions
    标题:A Novel And Efficient Preparation Of 2',3'-Dideoxynucleosides
    作者:Prisbe,Ernest J.; Et Al
    参考文献:Synthetic Communications 日期:1985 卷标:15(5) 页码:401-9]

    = 85326-06-3
    反应条件:1.1 Reagents: Azobisisobutyronitrile,Tributylstannane Solvents: 1,4-Dioxane2.1 Reagents: Pyridine,Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran
    标题:Synthesis And 1H And 13C Nmr Spectral Characteristics Of 8-Bromo-2',3'-Dideoxyguanosine And 8-Bromo-2',3'-Dideoxyinosine
    作者:Zeidler,Joanna; Et Al
    参考文献:Nucleosides & Nucleotides 日期:1996 卷标:15(5) 页码:1077-1095]

    2004-07-1 = 85326-06-3
    反应条件:1.1 -2.1 Catalysts: Adenosine Deaminase Solvents: Water
    标题:Enzymic Synthesis Of 2',3'-Dideoxyguanosine
    作者:Nair,Vasu; Et Al
    参考文献:Synlett 日期:1991 卷标:(10) 页码:753-4]

    64350-24-9 = 85326-06-3
    反应条件:1.1 Reagents: 2-(Acetyloxy)-2-Methylpropanoyl Bromide Solvents: Acetonitrile,Water; 1 H,Rt1.2 Reagents: Zinc Alloy,Base,Zn,Cu; 10 Min,Rt2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Rt
    标题:Crystal Structure Of Metacavir Ethanol Solvent Compound
    作者:Liu,Cai-Lian; Et Al
    参考文献:Huaxue Shiji 日期:2013 卷标:35(1) 页码:52-54]

    97-72-3 + 118-00-3 = 85326-06-3
    反应条件:1.1 Reagents: Hexamethyldisilazane Solvents: Dimethylformamide1.2 Solvents: Pyridine1.3 Reagents: Methanol2.1 Reagents: Imidazole Solvents: Dimethylformamide3.1 Solvents: Dimethylformamide4.1 Reagents: 1,3-Dimethyl-2-Phenyl-1,3,2-Diazaphospholidine5.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran6.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol7.1 Reagents: Ammonia Solvents: Methanol
    标题:General Syntheses Of 2',3'-Dideoxynucleosides And 2',3'-Didehydro-2',3'-Dideoxynucleosides
    作者:Chu,C. K.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(9) 页码:2217-25]

    118-00-3 = 85326-06-3
    反应条件:1.1 -2.1 -3.1 Catalysts: Adenosine Deaminase Solvents: Water
    标题:Enzymic Synthesis Of 2',3'-Dideoxyguanosine
    作者:Nair,Vasu; Et Al
    参考文献:Synlett 日期:1991 卷标:(10) 页码:753-4]

    118-00-3 = 85326-06-3
    反应条件:1.1 -2.1 Solvents: Acetonitrile; 10 Min,-45 °C; 1 H,Cooled; 20 H,Rt3.1 Reagents: Zinc Solvents: Dimethylformamide; 1 H,Rt4.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 12 H,0.4 Mpa,Rt5.1 Reagents: Methylamine Solvents: Methanol; 5 H,Rt
    标题:Synthesis And Anti-Hiv Activity Of A Series Of 6-Modified 2',3'-Dideoxyguanosine And 2',3'-Didehydro-2',3'-Dideoxyguanosine Analogs
    作者:Xie,Lujia; Et Al
    参考文献:Chinese Journal Of Chemistry 日期:2013 卷标:31(9) 页码:1207-1218
鸟苷置于palladium On Activated Charcoal 咪唑,Sodium Hydroxide,偶氮二异丁腈,四丁基氟化铵,氨,氢气,三正丁基氢锡体系中,用 四氢呋喃,甲醇,N,N-二甲基甲酰胺,苯 作为反应溶剂,50.0~65.0 °C,206.84 Kpa 条件下,反应 38.0H,反应生成 2',3'-二脱氧鸟苷
参考文献:General Syntheses Of 2',3'-Dideoxynucleosides And 2',3'-Didehydro-2',3'-Dideoxynucleosides
标题:General Syntheses Of 2',3'-Dideoxynucleosides And 2',3'-Didehydro-2',3'-Dideoxynucleosides
摘要:
DOI:10.1021/jo00270A036

海关参考信息

专利信息


专利号:US-8314209-B2
优先权日:2007-12-12
标 题 :Lipid-assisted synthesis of polymer compounds and methods for their use
发明人：RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO
权利人:RAJAMANI SUDHA; OLASAGASTI FELIX; DEAMER DAVID W; BENNER SEICO; UNIV CALIFORNIA
摘要:The invention herein disclosed provides for methods for the synthesis of polymers from monomers. In particular the method provides for the synthesis of polynucleotides from mononucleotides in the absence of catalytic enzymes. The method comprises providing an aqueous solution having a plurality of phospholipid molecules and monomer molecules; subjecting the aqueous solution to fluctuating temperature conditions; subjecting the aqueous solution to fluctuating cycles of drying and hydrating conditions; subjecting the aqueous solution to fluctuating [H + ] conditions; the fluctuating conditions thereby allowing formation of a chemical bond between at least two monomers to create a polymer. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:WO-9323413-A1
优先权日:1992-05-13
标 题:Synthesis of nucleotide monomers
发明人：BEIGELMAN LEONID; MATULIC-ACADEMIC JASENKA
权利人:RIBOZYME PHARM INC
摘要:Methods for synthesis of 2',3'-dideoxycytidine, 2',3'-dideoxyguanosine, 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine and 2',3'-dideoxyguanosine, and 3'-O-benzoyl-2'-deoxyribonucleoside.

专利号:US-9732112-B2
优先权日:2010-05-28
标 题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
发明人：MA ZHAOCHUN; MULLAH KHAIRUZZAMAN BASHAR; EASON ROBERT G
权利人:LIFE TECHNOLOGIES CORP
摘要:Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

专利号:US-5859233-A
优先权日:1996-02-21
标 题 :Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
发明人：HIRSCHBEIN BERNARD L; FEARON KAREN L; GRYAZNOV SERGEI M; MCCURDY SARAH N; NELSON JEFFREY S; SCHULTZ RONALD G
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides a method of synthesizing oligonucleotide N3'->P5' phosphoramidates using an amine-exchange reaction of phosphoramidites in which a -deprotected 3'-amino group of a solid phase supported oligonucleotide chain is exhanged for the amino portion of a 5'-phosphoramidite of an incoming monomer which has a protected 3'-amino group. The resulting internucleotide phosphoramidite linkage is then oxidized to form a stable protected phosphoramidate linkage. The method of the invention greatly improves product yields and reduces reagent usage over currently available methods for synthesizing the above class of compound.

专利号:US-5780617-A
优先权日:1990-05-29
标题 :Synthesis of liponucleotides
发明人：VAN DEN BOSCH HENK; VAN WIJK GYSBERT M T; KUMAR RAJ; HOSTETLER KARL Y
权利人:NEXSTAR PHARMACEUTICALS INC
摘要:A process for the preparation of glycerol di- or triphosphate derivatives comprising coupling the phosphate group of a glycerol monophosphate derivative in which one of the phosphate hydroxyls is replaced by a leaving group, with the terminal phosphate group of a mono- or diphosphate compound or a salt thereof, in the presence of a basic catalyst, under anhydrous conditions.

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合成参考文献


参考文献:10.1002/bmc.1667
摘要:Zhang Y, Huang X, Jiang Z, Huang X, Hu Y, Zhu D, Zhang S, Wang J, Zhang L. Simultaneous determination of metacavir and its metabolites in rat plasma using high-performance liquid chromatography with tandem mass spectrometric detection (LC-MS/MS). Biomed Chromatogr. 2012 Mar;26(3):363–70. doi: 10.1002/bmc.1667.
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