CAS: 85618-20-8; N-Heptyl β-D-Thioglucoside

该化合物是一种非电离性硫酸盐,广泛用于生物化学和生物物理研究,用于膜蛋白溶解和稳定.它的七基烷基链和硫基甲酸酯头组提供平衡的缺水性,能够有效地干扰脂重的两层,同时保持蛋白的完整性.与传统的洗涤剂相比,它提供了更好的稳定性和降低饱和风险,使之适合于晶体学和功能分析等敏感应用.在碱性条件下,硫酸盐基结合加强了化学稳定性,扩大了其在不同实验条件下的效用.它的温和高效溶解特性使得它成为在类似本地状态研究薄膜蛋白的一个宝贵工具.

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相似化合物

85618-21-9 7473-36-1 13533-58-9

上下游产品

CAS号61198-95-6 n-heptyl 2,3,4,... | CAS号629-04-9 1-溴庚烷 | CAS号40591-65-9 2-(2,3,4,6-四邻乙酰... | CAS号572-09-8 2,3,4,6-四乙酰氧基-a... | CAS号604-68-2 α-D-葡萄糖五乙酸酯

合成工艺路线路线简述

    N-Heptyl 2,3,4,6-Tetra-O-Acetyl-1-Thio-β-D-Glucopyranoside置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应生成 庚基-β-D-硫代吡喃葡萄糖苷
    参考文献:烷基β-D-硫代吡喃葡萄糖苷的合成及表面性质
    标题:烷基β-D-硫代吡喃葡萄糖苷的合成及表面性质
    摘要:烷基硫糖苷是一类非离子的基于糖的含硫表面活性剂和生物试剂.用helferich方法立体选择性地制备了具有不同烷基链长(n = 6-12)的表面活性剂1,2-反烷基β-D-硫代吡喃葡萄糖苷.主要研究了它们的性质,包括hlb值,Log P值,水溶性,泡沫性质,乳化性质,表面性质和热致液晶性质.结果表明,随着烷基链长的增加,Log B值增加,其hlb值和水溶性降低.烷基β-D-硫葡糖苷已经不溶于n>=10的水中.在临界胶束浓度(cmc)时,两种β-D-硫代吡喃葡萄糖苷(n = 8,9)都将相关水溶液的表面张力降低至近29 Mn.m-1.,它们还具有优异的起泡能力和泡沫稳定性.壬基β-D-硫代吡喃葡萄糖苷对正辛烷/水系统和甲苯/水系统均具有非常好的乳化性能.观测到烷基β-D-硫代吡喃葡萄糖苷(n = 6-12)具有热致液晶特性.
    DOI:10.1016/j.Molliq.2018.11.134

    海关参考信息

    专利信息


    专利号:US-2001049117-A1
    优先权日:1998-08-20
    标 题 :Analogs of udp-murnac peptides, assays, kits and related methods of their use
    发明人:AXELROD HELENA R; BRANSTROM ARTHUR A
    摘要:General compositions and methods for detecting Lipid I, Lipid II and peptidoglycan synthesis is disclosed. A method of screening for potential antibacterial agents is provided which requires bacterial membrane preparations or enriched enzyme preparations including at least one bacterial enzyme involved in the synthesis of Lipid I from UDP-MurNAc pentapeptide and undecaprenyl phosphate, at least one bacterial enzyme involved in the synthesis of Lipid II from Lipid I and UDP-GlcNAc and one or more bacterial enzymes involved in the further processing of Lipid II toward the downstream synthesis of peptidoglycan. The methods disclosed herein further provides a labeled UDP-MurNAc-peptide capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid I and a labeled UDP-GlcNAc capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid II. Conditions for further processing of Lipid II toward the downstream synthesis of peptidoglycan are also discribed.

    专利号:US-8067204-B2
    优先权日:2005-12-15
    标 题 :Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin
    发明人:SUGIURA NOBUO; SHIMOKATA SATOSHI; KIMATA KOJI
    权利人:SUGIURA NOBUO; SHIMOKATA SATOSHI; KIMATA KOJI; SEIKAGAKU KOGYO CO LTD
    摘要:A method for producing a chondroitin sugar chain comprises reacting a glucuronic acid donor, an N-acetyl galactosamine donor, a sugar receptor and a bacterial cell enzyme which synthesizes chondroitin in the presence of a surfactant. The surfactant is selected from polyoxyethylene octadecyl amine, n-decanoyl-N-methylglucamide, sodium cholate, n-octyl-β-D-thioglucopyranoside, n-nonyl-β-D-thiomaltopyranoside, sucrose monocholate, sucrose monocaprate, and sucrose monolaurate. The chondroitin sugar chain has all the following properties: a weight average molecular weight: 50,000 or more when measured by gel filtration chromatography; it is completely degraded to disaccharides with chondroitinase ABC; and when the sugar chain is decomposed with chondroitinase ABC and the decomposed products are subjected to a disaccharide analysis, substantially all of them correspond to an unsaturated disaccharide unit of chondroitin.

    专利号:US-2009263867-A1
    优先权日:2005-12-15
    标 题 :Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin

    专利号:EP-1964924-B1
    优先权日:2005-12-15
    标 题 :Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin

    专利号:US-9617533-B2
    优先权日:2011-03-10
    标题:Composition for synthesizing protein with reduced lipopolysaccharide contamination, method for producing protein using said composition
    发明人:KANAMORI TAKASHI; HAYAMI YUKI; KOJOH KANEHISA; UEDA TAKUYA; TSUIHIJI KUMIKO; FUSE TOMOE; NAKAMURA MIKIKO; KATO SHIZUE
    权利人:GENEFRONTIER CORP; UNIV TOKYO; THE UNIVERISTY OF TOKYO
    摘要:According to the present invention, a composition possessing cell-free protein synthesis activity with reduced contaminating lipopolysaccharide, and a method for producing a protein using the same are provided. When ribosome display is performed using the composition and method for protein production of the present invention, the background that is caused by non-specific binding is reduced, so that a nucleic acid that encodes the desired polypeptide can be selected with high accuracy and high efficiency.

    专利号:EP-1964924-A1
    优先权日:2005-12-15
    标 题:Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin
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    主要参考文献

    [参考文献]: K Nagai, Et Al. Biosynthesis Of Monosulfogangliotriaosylceramide And Gm2 By N-Acetylgalactosaminyltransferase From Rat Brain. J Biochem. 1987 May;101(5):1115-27.
    [参考文献]: T Ohyashiki, Et Al. Ca2+-Dependent Atp Hydrolysis Of The Porcine Intestinal Brush-Border Membranes. Biochim Biophys Acta. 1987 Aug 7;902(1):46-52.
    [参考文献]: T Shimamoto, Et Al. Value Of Heptyl-Beta-D-Thioglucoside, A New Nonionic Detergent, In Studies On Membrane Proteins. J Biochem. 1985 Jun;97(6):1807-10.

    合成参考文献


    参考文献:10.1016/j.jmb.2004.07.044
    摘要:Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol. 2004 Sep 10;342(2):571–83. doi: 10.1016/j.jmb.2004.07.044.
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