CAS: 88887-87-0; 1-Methylcyclopropanamine Hydrochloride

该化合物是一种环丙胺衍生物,用作有机合成和制药应用的多用途中间体;环丙烷环环形结构具有独特的消毒和电子特性,对制造复杂的分子具有价值;盐盐状增强稳定性和溶性,便利处理和储存;该化合物因其具有调节药用植物特性的能力,在生物活性分子(包括潜在的药物候选分子)的开发方面特别有用;它通常用于再处理或核生殖器替代等反应;高纯度可用于满足严格的研究和工业要求;建议在惰性条件下进行适当处理以保持完整性.

英文名称1-Methylcyclopropanamine Hydrochloride
中文名称1-甲基环丙胺盐酸盐
IUPAC名称1-methylcyclopropan-1-amine hydrochloride
其它别名(1 - 甲基环丙基)胺saltdata:Hcl; 1-Methylcyclopropylamine Hydrochloride
CAS编号88887-87-0
MFCD编号:MFCD11109576
EINECS号:812-741-4
分子式:C4H10ClN
分子量:107.58
产品CID: 1909212
产品分类有机原料→分子砌块→脂肪环类化合物→环丙烷类化合物

相似结构搜索
InChIKey: GHILZUOTUJGCDH-UHFFFAOYSA-N
InChI=1S/C4H9N.ClH/c1-4(5)2-3-4;/h2-3,5H2,1H3;1H…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

2088414-03-1 2418643-28-2 174886-06-7

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

CAS号251661-01-5 N-B°C-1-甲基环丙胺 | CAS号6914-76-7 1-甲基环丙烷-1-羧酸 | CAS号22936-83-0 1-甲基环丙胺

合成工艺路线路线简述

911392-15-9 = 88887-87-0
反应条件:1.1 Reagents: Hydrochloric Acid,Atomic Chlorine Solvents: Tetrahydrofuran,Water1.2 Reagents: Acetic Acid,Zinc1.3 Solvents: Diethyl Ether
标题:Hydrazines And Azides Via The Metal-Catalyzed Hydrohydrazination And Hydroazidation Of Olefins
作者:Waser,Jerome
参考文献:2006]

6914-76-7 = 88887-87-0
反应条件:1.1 Reagents: Triethylamine,Diphenylphosphoryl Azide Solvents: Tert-Butanol; Overnight,75 °C1.2 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane,Water; 2 H,Rt
标题:Cell-Active Small Molecule Inhibitors Of The Dna-Damage Repair Enzyme Poly(Adp-Ribose) Glycohydrolase (Parg): Discovery And Optimization Of Orally Bioavailable Quinazolinedione Sulfonamides
作者:Waszkowycz,Bohdan; Smith,Kate M.; Mcgonagle,Alison E.; Jordan,Allan M.; Acton,Ben; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2018 卷标:61(23) 页码:10767-10792]

911392-15-9 = 88887-87-0
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran1.2 Reagents: Acetic Acid,Zinc Solvents: Acetone1.3 Reagents: Hydrochloric Acid Solvents: Diethyl Ether
标题:Methylenecyclopropane
作者:Sieburth,Scott Mcn.; Hiel,Gary; Roy,Marie-Noelle
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2012 卷标:1 页码:1-3]

911392-15-9 = 88887-87-0
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran1.2 Reagents: Acetic Acid,Zinc Solvents: Acetone1.3 Reagents: Hydrochloric Acid Solvents: Diethyl Ether
标题:Hydrazines And Azides Via The Metal-Catalyzed Hydrohydrazination And Hydroazidation Of Olefins
作者:Waser,Jerome; Gaspar,Boris; Nambu,Hisanori; Carreira,Erick M.
参考文献:Journal Of The American Chemical Society 日期:2006 卷标:128(35) 页码:11693-11712]

6914-76-7 = 88887-87-0
反应条件:1.1 Reagents: Triethylamine Solvents: Acetone,Water1.2 Reagents: Ethyl Chloroformate Solvents: Acetone1.3 Reagents: Sodium Azide Solvents: Water1.4 Solvents: Toluene1.5 Reagents: Hydrochloric Acid Solvents: Water
标题:Deamination Reactions. 44. Decomposition Of 1-Alkylcyclopropanediazonium Ions
作者:Kirmse,Wolfgang; Rode,Jutta; Rode,Klaus
参考文献:Chemische Berichte 日期:1986 卷标:119(12) 页码:3672-93

1-甲基环丙烷-1-羧酸置于叠氮磷酸二苯酯,三乙胺,盐酸体系中,用叔丁醇,1,4-二氧六环,水作为反应溶剂,化学反应 2.0H,以51%的收率获得产物1-甲基环丙胺盐酸盐
参考文献: Parg Inhibitory Compounds[fr] Composés Inhibiteurs De Parg
标题: Parg Inhibitory Compounds[fr] Composés Inhibiteurs De Parg
摘要:本发明涉及作为parg(poly Adp-Ribose Glycohydrolase)酶活性抑制剂的化合物i的公式,其中r1A,R1B,R1C,R1D,R1E,W,X1,X2,X3,X4,X5,X6,X7,C分别如本文所定义.本发明还涉及制备这些化合物的方法,包括含有它们的药物组合物,以及它们在治疗增殖性疾病(如癌症)以及其他涉及parg活性的疾病或症状中的用途.

专利信息

专利号:US-RE50050-E
优先权日:2013-06-21
标题 :Pyrimidinedione compounds
发明人：OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; LU PUPING; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER
权利人:MYOKARDIA INC
摘要:Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

专利号:EP-3848356-A1
优先权日:2020-01-07
标题 :Aryl-n-aryl derivatives for treating a rna virus infection
权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE
摘要:The present invention relates to a compound of formula (I):n nwherein: n X 2 represents a -CO-NR k - group, a -NR' k -CO- group, a -O- group, a -CO- group, a -SO 2 -group, a -CS-NH- group, a -CH 2 -NH-, an ngroup, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y 2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C 1 -C 4 )alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a bridged bicycloalkyl group, a piperidinyl group, a (C 1 -C 4 )alkenyl group, a -PO(OR a )(OR b ) group, or a -CR 1 R 2 R 3 group, or any of its pharmaceutically acceptable salt. n The present invention further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.