专利号:WO-2023031841-A1 优先权日:2021-09-03 标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates 发明人:MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
专利号:WO-2025074315-A3 优先权日:2023-10-05 标 题 :An improved process for the synthesis of all (e)-hepta prenol (c35-oh) 发明人:BNS RAJU; NIPURTE PRIYANKA; KALE KOMAL; VORA PARIN K; MEHTA DILIP 权利人:SYNERGIA LIFE SCIENCES PVT LTD 摘要:The present disclosure relates to an improved process for the regio- and stereospecific synthesis of polyprenyl compounds. More particularly it discloses regio- and stereospecific synthesis of (2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14, 18, 22,26 heptane-1-ol which finds use in the synthesis of Vitamin K2-7.
专利号:US-2024217941-A1 优先权日:2021-04-28 标题 :Ring closure of benzoquinones containing an unsaturated side chain using a basic catalyst 发明人:BONRATH WERNER; KUENZI ROLF; TIRPANCI MELTEM; NETSCHER THOMAS 权利人:DSM IP ASSETS BV 摘要:The present invention relates to the formation of compound of the formula (I) by a ring closure reaction of the compound of the formula (II) in the presence of a catalytic amounts of a base. It has been found that this reaction is very efficient and offers for example an efficient pathway for the synthesis of 3,4-dehydro-α-tocotrienol respectively α-tocotrienol and α-tocopherol.
专利号:US-2024228454-A1 优先权日:2021-04-28 标 题 :Ring closure of benzoquinones containing an unsaturated side chain using a base in two-phase system 发明人:BONRATH WERNER; KUENZI ROLF 权利人:DSM IP ASSETS BV 摘要:The present invention relates to the formation of compound of the formula (I) by a ring closure reaction of the compound of the formula (II) in the presence of a base in a two-phase system. It has been found that this reaction is very efficient and offers for example an efficient pathway for the synthesis of 3,4-dehydro-α-tocotrienol respectively a-tocotrienol and a-tocopherol.
专利号:WO-2011117324-A3 优先权日:2010-03-23 标 题:Process for the preparation of vitamin k2 发明人:SKATTEBOEL LARS; AUKRUST INGER REIDUN; SANDBERG MARCEL 权利人:KAPPA BIOSCIENCE AS; SKATTEBOEL LARS; AUKRUST INGER REIDUN; SANDBERG MARCEL 摘要:A new process for making polyprenols is described as well as the use of these building blocks in the synthesis of Vitamin K2. The process involves reaction of a compound of formula (X) with a compound of formula (XI) in the presence of a base so as to form a compound of formula (XII) and conversion of that compound into a compound of formula (XIII).
专利号:US-12168649-B2 优先权日:2018-08-17 标 题 :Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives 发明人:WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL 权利人:BASF SE 摘要:The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.
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