CAS: 1115-59-9; H-Ala-Oet.Hcl

相似化合物

617-27-6 6331-09-5 64892-53-1

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CAS号64-17-5 乙醇 | CAS号56-41-7 L-丙氨酸 | CAS号51814-53-0 γ-(p-Anisidino)... | CAS号245078-14-2 (2S)-2-((氯(苯氧基)... | CAS号78603-91-5 (S)-2-氨基-1,1-二苯... | CAS号61275-22-7 H-丙氨酸-NHME盐酸盐 | CAS号54159-18-1 2-(苄基氨基)丙酸乙酯 | CAS号2749-11-3 L-氨基丙醇 | CAS号104873-98-5 (3S)-3-甲基-1,4-苯... | CAS号5673-69-8 ethyl 2-[2-(phe...

L-丙氨酸 以 乙醇 用作溶剂,以98%的收率获得l-丙氨酸乙酯盐酸盐
参考文献:Chiral Auxiliaries
标题:Chiral Auxiliaries
摘要:这项发明涉及一般式(i)的新化合物:##str1## 其中两个r.Sup.1基团是相同的较低烷基基团或共同形成较低烷基基团;R.Sup.2和r.Sup.3都不同,可选择来自氢原子或有机基团;X和x',可能相同也可能不同,可选择来自o,S和nr,其中r代表一个有机基团;星号表示r.Sup.2和r.Sup.3的构型使化合物(i)基本上处于对映纯4R-或4S-形式.这些化合物是有用的手性辅助剂,可以将一系列包含可逆地与3位氨基团结合的丙酰基团等具有手性中心的基团轻松地耦合到其中.

专利信息

专利号:US-2024182642-A1
优先权日:2022-11-23
标 题:Green synthesis of amino acid based poly(ester urea)s
发明人：OLSEN BRADLEY DAVID; FRANSEN KATHARINA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods of synthesizing poly(ester urea)s.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-8703747-B2
优先权日:2008-07-23
标题 :Aminophosphinic derivatives that can be used in the treatment of pain
发明人：ROQUES BERNARD; PORAS HERVÉ; FOURNIE-ZALUSKI MARIE-CLAUDE
权利人:ROQUES BERNARD; PORAS HERVÉ; FOURNIE-ZALUSKI MARIE-CLAUDE; PHARMALEADS
摘要:The present invention relates to a compound of the following general formula (I): R 1 —NH—CH(R 2 )—P(â•?O)(OR 3 )—CH 2 —C(R 4 )(R 5 )—CONH—CH(R 6 )—COOR 7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R 1 represents a —C(â•?O)—O—C(R 8 )(R 9 )—OC(â•?O)—R 10 group; R 2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R 3 represents a hydrogen atom or a —C(R 12 )(R 13 )—OC(â•?O)—R 14 group; R 4 and R 5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R 4 represents a hydrogen atom and R 5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R 6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R 7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR 18 , —CHR 19 —OC(â•?O)OR 20 and —CHR 19 —OC(â•?O)OR 20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more avantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.

专利号:US-7732436-B2
优先权日:2003-05-19
标 题 :Preparation of hymenialdisine derivatives and use thereof
发明人：TEPE JETZE J
权利人:UNIV MICHIGAN STATE
摘要:The synthesis and biological activity of indoloazepines and acid amine salts thereof which are structurally related to naturally-occurring hymenialdisine is disclosed. Naturally-occurring hymenialdisine obtained from the sponge is a potent inhibitor of production of cytokines interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α). The chemically-synthesized indoloazepines of the invention also inhibit production of IL-2 and TNF-α. The indoloazepines are useful for treating inflammatory diseases, particularly diseases associated with kinases NF-κB or GSK-3β activation or NF-κB activated gene expression products. The indoloazepines are useful for the treatment of cancer by the inhibition of kinases CHK1 and CHK2.

专利号:CN-102532199-A
优先权日:2012-02-29
标 题:Structure and Synthesis of Novel Benzyl Phosphoramidate Prodrugs of Nucleoside Compounds