CAS: 124-42-5; Acetamidine Hydrochloride

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1040352-82-6 1452099-14-7 36896-17-0

上下游产品

CAS号5426-04-0 N-hydroxyethani... | CAS号75-05-8 乙腈 | CAS号60-35-5 乙酰胺 | CAS号64-17-5 乙醇 | CAS号118493-85-9 acetamide oxime | CAS号2208-07-3 乙基乙酰亚胺盐酸盐 | CAS号7664-41-7 氨 | CAS号5426-59-5 6-溴-2-甲基喹唑啉-4(3H)-酮 | CAS号45533-87-7 4-羟基甲基-2-甲基-1H-咪唑 | CAS号382-26-3 1,1,3,3,3-五氟-2-... | CAS号97653-57-1 4-fluoro-6-meth... | CAS号40497-30-1 4,6-二羟基-2-甲基嘧啶 | CAS号14273-42-8 5-Pyrimidineace... | CAS号14277-00-0 N'-phenylethani... | CAS号5053-43-0 2-甲基嘧啶 | CAS号90905-33-2 2-甲基-5-嘧啶甲醛 | CAS号461-98-3 4-氨基-2,6-二甲基嘧啶

甲基乙酰亚胺酯盐酸盐置于氨体系中,用 甲醇 用作溶剂,化学反应 2.0H,以97.5%的收率获得盐酸乙脒
参考文献:一种盐酸乙脒的制备方法
标题:一种盐酸乙脒的制备方法
摘要:本发明提供了一种盐酸乙脒的制备方法.具体地,本发明通过采用反向滴加的方式,将中间产物亚乙脒滴加到氨甲醇中生成稳定的盐酸乙脒,所述反向滴加方式不仅有效抑制了亚乙脒的分解,而且盐酸乙脒的收率可达95%以上.本发明的方法操作安全,产率高,能耗少,非常适合大规模应用.

专利信息

专利号:US-11891375-B2
优先权日:2021-07-26
标 题 :Method for the synthesis of 2,4-dimethylpyrimidin-5-ol, intermediates, and method for the synthesis of Lemborexant using the intermediates
发明人：AKHATOU ABDESLAM; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A method is for the synthesis of 2,4-dimethylpyrimidin-5-ol, which can be used as an intermediate compound in the synthesis of Lemborexant. The method includes reacting a nitrophenyl compound with N,N-dimethylformamide diethyl acetal.

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人：HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.

专利号:US-2006167025-A1
优先权日:2004-12-22
标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
发明人：BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).

专利号:US-8252927-B2
优先权日:2008-07-22
标题:Synthesis of substituted 4-amino-pyrimidines
发明人：KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD
权利人:KARGE REINHARD; LETINOIS ULLA; SHIEFER GERHARD; DSM IP ASSETS BV
摘要:The present invention is directed to a process for the manufacture of compounds of formula IV wherein R 1 is an amino protecting group, and R 2 is hydrogen or C 1-10 alkyl, comprising a) reacting a compound of formula Ia, wherein M + is a cation, preferably selected from the group consisting of Li + , Na+, K + , ½ Mg 2+ and ½ Zn 2+ , (formula 1 a ) with an ammonium salt NH 4 + X − , wherein X − is an anion, preferably selected from the group consisting of chloride, bromide, sulfate and acetate, in a solvent to a compound of formula II b) reacting a compound of formula II with a nitrile R 2 —CN in the presence of a base to a compound of formula IV. The present invention is further directed to compounds of formula II and their use for the manufacture of vitamin B 1 .