CAS: 15181-11-0; 1,3-Di-Tert-Butyl-5-Methylbenzene

该化合物其结构特征为:3,5,5个位置上用两组乙型丁基苯取代甲苯骨柱,该化合物一般是无色的,淡黄色的,沸点相对较高的,表明其大片替代成分会助长消毒障碍;已知其在水中的溶解性较低,但在有机溶剂中溶性良好,因此在各种化学应用中有用; 乙型丁基苯组的存在增强了其热稳定性和对氧化的抗药性,这有利于工业应用,特别是燃料和润滑油中的添加剂; 此外,3,5-二-乙型丁基丁基苯的毒性较低,使它在某些化学过程中成为更安全的替代物; 其独特性质也使其在与聚合物化学和材料科学有关的研究中引起兴趣;

结构式图片

相似化合物

1460-02-2 1014-60-4 98-19-1

上下游产品

tertiary butyl chloride 4-tert-butyltoluene m-t-butyltoluene 2,4,4-trimethyl-1-pentene 1,5-di-tert-butyl-3-methyl-2-nitrobenzene 3,5-di-tert-butyl-benzoyl chloride tert-butyl-3-methyl-2,4-dinitro-benzene1,5-di-tert-butyl-3-methyl-2,4-dinitro-benzene 3,5-di-tert-butylbenzoic acid

合成工艺路线路线简述

    4-叔丁基甲苯置于三氯化铝体系中,20.0~35.0 °C,399.97 Pa 条件下,反应生成3,5-二叔丁基甲苯
    参考文献:Lacourt,Bulletin Des Societes Chimiques Belges,1929,Vol. 38,P. 1,4
    标题:Lacourt,Bulletin Des Societes Chimiques Belges,1929,Vol. 38,P. 1,4

    海关参考信息

    专利信息


    专利号:US-11999757-B2
    优先权日:2017-11-01
    标 题:Synthesis of boronate ester derivatives and uses thereof
    发明人:BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
    权利人:MELINTA SUBSIDIARY CORP
    摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

    专利号:US-10669292-B2
    优先权日:2014-05-05
    标 题 :Synthesis of boronate salts and uses thereof
    发明人:HECKER SCOTT; BOYER SERGE
    权利人:REMPEX PHARMACEUTICALS INC
    摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

    专利号:US-9315483-B2
    优先权日:2007-09-13
    标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
    发明人:JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
    权利人:CONCERT PHARMACEUTICALS INC
    摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

    专利号:US-2005014954-A1
    优先权日:2001-11-22
    标 题:Pyrrole synthesis
    发明人:OHRLEIN REINHOLD; BAISCH GABRIELE
    摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

    专利号:US-8026383-B2
    优先权日:2001-07-06
    标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
    发明人:OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
    权利人:BASF SE
    摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

    专利号:US-6380416-B2
    优先权日:1997-06-13
    标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
    发明人:ZHANG XUMU
    权利人:PENN STATE RES FOUND
    摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.
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    合成参考文献


    参考文献:10.1055/s-0030-1258736
    摘要:Wu J, Zhang X, Li J, Qu H, Chi C. Conjugate Additions When You Least Expect Them. Synfacts. 2010 Oct 21;2010(11):1245. doi: 10.1055/s-0030-1258736.
    参考文献:10.1055/s-0040-1707255
    摘要:Talukdar R. Synthetically Important Ring-Opening Acylations of Alkoxybenzenes. Synthesis. 2020 Sep 08;52(24):3764–80. doi: 10.1055/s-0040-1707255.
    参考文献:10.1055/s-0040-1706120
    摘要:Frustrated Lewis Pair Catalyzed Asymmetric Hydrogenation of Imines. Synfacts. 2021 Jan 20;17(02):0202. doi: 10.1055/s-0040-1706120.
    参考文献:10.1055/s-0037-1611597
    摘要:Rhodium-Catalyzed Asymmetric Hydroarylation of Chromenes. Synfacts. 2019 May 20;15(06):0643. doi: 10.1055/s-0037-1611597.
    参考文献:10.1055/s-0034-1378891
    摘要:Xie J, Zhou Q, Yuan M, Yang X. Enantioselective Synthesis of Chiral 1,2-Amino Alcohols via Asymmetric Hydrogenation of α-Amino Ketones with Chiral Spiro Iridium Catalysts. Synthesis. 2014 Aug 06;46(21):2910–6. doi: 10.1055/s-0034-1378891.
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