CAS: 1638-63-7; 2-Chloro-2-Oxo-1-Phenylethyl Acetate

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2-acetoxy-2-phenylacetic acid MANDELIC ACID acetyl chloride phosphorus pentachloride 1-acetoxy-3-diazo-1-phenyl-acetone 1-acetoxy-3-chloro-1-phenyl-2-propanone benzylglyoxal benzaldehyde

扁桃酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,反应生成乙酰扁桃酰氯
参考文献:新型丙酮酸脱氢酶激酶抑制剂的设计,合成与评价
标题:新型丙酮酸脱氢酶激酶抑制剂的设计,合成与评价
摘要:目的:目前的工作描述了作为丙酮酸脱氢酶激酶 (Pdk) 抑制剂的新型化合物的合成和生物学评价.这些药物应该成为一种新的治疗方法,用于治疗通过控制血乳酸水平而改善的病症.方法:制备属于 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-甲基丙酰胺和 1,2,4-苯并噻二嗪 1,1-二氧化物的四个系列化合物,并作为 Pdk 抑制剂进行评估.结果:新合成的 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-甲基丙酰胺在结构上与先前报道的参考化合物 4 和 5 相关,被发现是有效的 Pdk 抑制剂(即 10D:Ic50 = 41 Nm).1,2,4-苯并噻二嗪 1,置于6 位带有 (甲基/三氟甲基)-丙酰胺部分的 1-二氧化物也被设计为 N-(4-(N-烷基/芳烷基氨磺酰基)苯基)-2-羟基-2-的构象限制闭环类似物甲基丙酰胺.他们中的大多数被发现不如他们的开环类似物有效.有趣的是,4-位烃侧
Doi:10.2174/1573406418666220819102627

专利信息

专利号:US-7098354-B2
优先权日:2002-10-25
标 题:Racemoselective synthesis of rac-diorganosilylbis(2-methylbenzo[e]indeyl)zirconium compounds
发明人：DAMRAU HANS-ROBERT; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; LELONG JEAN-FRANCOIS
权利人:BASELL POLYOLEFINE GMBH
摘要:The present invention relates to a specific process for the diastereoselective synthesis of rac-diorganosilylbis(2-methylbenzo[e]indenyl)zirconium compounds of the formula I, n nby reacting the silyl-bridged bisindenyl ligand with a dihalozirconium bis(3,5-di-tert-butylphenoxide)-base adduct to form the diorganosilylbis(2-methylbenzo[e]indenyl)zirconium bis(3,5-di-tert-butylphenoxide) and subsequently replacing the phenoxide groups by X using suitable replacement reagents to give the compound of the formula I; where the substituents X can be identical or different and are each F, Cl, Br, I or linear, cyclic or branched C 1-10 -alkyl; and the substituents R can be identical or different and are each linear, cyclic or branched C 1-10 -alkyl or C 6-10 -aryl; and also to the use of these compounds as catalysts.

专利号:US-7193099-B2
优先权日:2002-10-25
标 题:Racemoselective preparation of isolable ansa-metallocene biphenoxide complexes
发明人：DAMRAU HANS-ROBERT-HELLMUTH; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; LELONG JEAN-FRANCOIS
权利人:BASELL POLYOLEFINE GMBH
摘要:The invention relates to a process for preparing racemic metallocene biphenoxide complexes by reacting bridged transition metal complexes with cyclopentadienyl derivatives of alkali metals or alkaline earth metals and heating the reaction mixture obtained in this way to a temperature in the range from −78 to 250° C., to the corresponding metallocene biphenoxide complexes and to their use as catalysts or as constituents of catalysts for the polymerization of olefinically unsaturated compounds or as reagents or catalysts in stereoselective synthesis.

专利号:US-7358381-B2
优先权日:2002-10-25
标题 :Racemoselective preparation of bridged metallocene complexes having unsubstituted or 2-substituted indenyl ligands
发明人：DAMRAU HANS-ROBERT-HELLMUTH; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; LELONG JEAN-FRANCOIS; HURIEZ ERIC
权利人:BASELL POLYOLEFINE GMBH
摘要:The invention relates to a process for preparing racemic metallocene complexes by reacting transition metal complexes with cyclopentadienyl derivatives of alkali metals or alkaline earth metals and heating the reaction mixture obtained in this way to a temperature in the range from −78 to 250° C., to the corresponding metallocene complexes themselves and to their use as catalysts or as constituents of catalysts for the polymerization of olefinically unsaturated compounds or as reagents or catalysts in stereoselective synthesis.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-7619106-B2
优先权日:2002-10-25
标题:Preparation of partially hydrogenated rac-ansa-metallocene complexes
发明人：DAMRAU HANS-ROBERT-HELLMUTH; MUELLER PATRIK; GARCIA VALERIE; SIDOT CHRISTIAN; TELLIER CHRISTIAN; DUCHIRON STEPHANIE; LELONG JEAN-FRANCOIS
权利人:BASELL POLYOLEFINE GMBH
摘要:The invention relates to a process for preparing hydrogenated or partially hydrogenated, racemic ansa-metallocene complexes by reacting bridged or unbridged transition metal complexes with alkali metal compounds or alkaline earth metal compounds, heating the resulting reaction mixture to a temperature in the range from −78 to 250° C. and at least partially hydrogenating the reaction products in the presence of a suitable catalyst, to the corresponding hydrogenated or partially hydrogenated metallocenes and to their use as catalysts or as a constituent of catalysts for the polymerization of olefinically unsaturated compounds or as reagents or catalysts in stereoselective synthesis.

专利号:EP-1554297-B1
优先权日:2002-10-25
标题:Racemoselective synthesis of rac-diorganosilylbis(2-methylbenzo¬e; indeyl) zirconium componds