CAS: 1869-24-5; 2-(Trifluoromethyl)Benzenesulfonamide

上下游产品

CAS号776-04-5 邻三氟甲基苯磺酰氯

2-三氟甲基苯磺酰氯置于ammonium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应生成2-三氟甲基苯磺酰胺
参考文献:苯磺酰胺对碳酸酐酶ⅱ的抑制作用评价及分子对接分析
标题:苯磺酰胺对碳酸酐酶ⅱ的抑制作用评价及分子对接分析
摘要:摘要 磺胺类化合物是一类重要的化合物,可用作碳酸酐酶抑制剂.合成了9种不同的苯磺酰胺类化合物,通过酯酶法和分子对接研究了它们对碳酸酐酶ⅱ的抑制作用.结果表明,苯环上具有硝基和乙酰胺基团的化合物(Iid)-(Iig)表现出优异的碳酸酐酶ii抑制活性.分子对接表明,与对照抑制剂乙酰唑胺相比,化合物(Iid)-(Iig)对接在碳酸酐酶ii活性位点,显示出更高的结合能和更强的结合能力.Molinspiration对所有化合物的物理和化学性质进行了研究,显示出优异的药物样性质和adme性质.细胞毒性试验结果表明化合物(Iie)和(Iif)对hepg2和raw264.7细胞几乎无毒.综上所述,化合物(Iie)和(Iif)作为新型碳酸酐酶ii抑制剂具有一定的应用前景.
Doi:10.1134/s1068162021010283

专利信息

专利号:US-6960601-B2
优先权日:2001-09-24
标题 :Preparation and use of imidazole derivatives for treatment of obesity
发明人：SMITH ROGER A; O'CONNOR STEPHEN J; WIRTZ STEPHAN-NICHOLAS; WONG WAI C; CHOI SOONGYU; KLUENDER HAROLD C E; SU NING; WANG GAN; ACHEBE FURAHI; YING SHIHONG
权利人:BAYER PHARMACEUTICALS CORP
摘要:This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:CN-109824665-B
优先权日:2019-02-26
标题:Synthesis of N- ((2-phenylimidazo [1,2-a ] pyridin-3-yl) methyl) benzenesulfonamide compound

专利号:MX-2007009402-A
优先权日:2005-02-05
标题 :SEPARATION OF N-BUTILBENCENOSULFONAMIDE, SYNTHESIS OF BENCENOSULFONAMIDE DERIVATIVES AND USE OF N-BUTILBENCENOSULFONAMIDE AND DERIVATIVES OF BENCENOSULFONAMIDE IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIAS AND / OR CARCINOMA PROSTATE.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:CN-114702448-A
优先权日:2021-09-30
标题 :Synthesis method of trifluoromethylated tandem cyclization spiro-compound of cycloolefine