CAS: 214759-21-4; (2,4,6-Trifluorophenyl)Methanamine

上下游产品

1,3,5-trifluorobenzene 2,4,6-trifluorobenzaldehyde 2,4,6-trifluorobenzyl chloride 2,4,6-trifluorobenzonitrile 5-methoxy-2-(pyridin-2-yl)-N-(2,4,6-trifluorobenzyl)pyrimidin-4-amine 8-(2,4,6-trifluorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrazino[2,1-f]purine-2,4(1H,3H)-dione

2,4,6-三氟苯腈置于氢气体系中,40.0~45.0 °C,600.01 Kpa 条件下,以95 %的收率获得2,4,6-三氟苄胺
参考文献:一种催化加氢制备2,4,6-三氟苯甲胺的方法
标题:一种催化加氢制备2,4,6-三氟苯甲胺的方法
摘要:本发明涉及一种催化加氢制备2,4,6‑三氟苯甲胺的方法,属于精细化工技术领域.该方法是在羟基功能化离子液体(Il‑oh)中,以氯铂酸或铂盐提供铂源,首先获得高活性零价铂的离子液体催化体系,继而催化2,4,6‑三氟苯腈25‑50oc/0.5‑1.5Mpa氢解反应,制备2,4,6‑三氟苯甲胺.本发明提供方法更为安全,并且副反应较少,反应收率较高,不使用有机溶剂环境污染较轻,是一条较为绿色环保的工艺.

专利信息

专利号:US-10975096-B2
优先权日:2014-06-20
标题 :Synthesis of polycyclic-carbamoylpyridone compounds
发明人：CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
权利人:GILEAD SCIENCES INC
摘要:Methods of making compounds of Formula I are disclosed:

专利号:US-11248005-B2
优先权日:2019-07-08
标 题 :Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor
发明人：JADHAV HARISHCHANDRA SAMBHAJI; SHRIVASTAVA DHANANJAI; AHER UMESH PARASHARAM; DEOKAR SHARAD CHANDRABHAN; NALE DEEPAK BABASAHEB; HONRAO SURYAKANT TUKARAM; SINGH GIRIJ PAL
权利人:LUPIN LTD
摘要:Provided herein is a process for the intermediates used for preparation of HIV Integrase Inhibitor such as Bictegravir, Dolutegravir, Cabotegravir or their pharmaceutically acceptable salts.

专利号:US-10745342-B2
优先权日:2018-07-05
标 题 :Synthesis method of 2,4,6-trifluorobenzylamine
发明人：YUAN QILIANG; QIAN JIE; LAI XIN; CHEN HAIFENG; CHEN YINHAO; WANG CHAO
权利人:ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD; SHAOXING ZHONGKE BAIYUN CHEMICAL TECH CO LTD
摘要:The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.

专利号:EP-3527573-B1
优先权日:2014-06-20
标题:Synthesis of polycyclic-carbamoylpyridone compounds

专利号:AU-2018217236-B2
优先权日:2014-06-20
标 题:Synthesis of polycyclic-carbamoylpyridone compounds

专利号:AU-2018217236-A1
优先权日:2014-06-20
标 题 :Synthesis of polycyclic-carbamoylpyridone compounds