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专利信息

专利号:US-5962294-A
优先权日:1992-03-09
标题 :Compositions and methods for the identification and synthesis of sialyltransferases
发明人：PAULSON JAMES C; WEN XIAOHONG; LIVINGSTON BRIAN; GILLESPIE WILLIAM; KELM SORGE; BURLINGAME ALMA L; MEDZIHRADSZKY KATALIN
权利人:UNIV CALIFORNIA; CYTEL CORP
摘要:DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.

专利号:US-7994346-B2
优先权日:2001-11-06
标题 :Intermediates for the preparation of lipoxin A4 analogs
发明人：GROSSBACH DANJA; GUILFORD WILLIAM; SANDER MICHAEL
权利人:BAYER SCHERING PHARMA AG
摘要:This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A 4 analogs of the following formulas (I) and (II): n nwherein R 1 , R 2 , R 3 , R 4 and R 5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.

专利号:EP-0632831-B1
优先权日:1992-03-09
标题 :Nucleic acid, expressionvector and compositions for the identification and synthesis of recombinant sialyltransferases
发明人：PAULSON JAMES C; WEN XIAOHONG; LIVINGSTON BRIAN; GILLESPIE WILLIAM; KELM SORGE; BURLINGAME ALMA L; MEDZIHRADSZKY KATALIN
权利人:UNIV CALIFORNIA; CYTEL CORP
摘要:DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.

专利号:WO-2025029055-A1
优先权日:2023-07-31
标 题 :Therapeutic agent composition for treatment of immunopathies through mitochondrial transplantation
发明人：CHO MI-LA; CHUNG BYUNG HA; WOO JIN-SEOK; LEE SEON-YEONG; LEE A-RAM; JHUN JOO-YEON; LEE YEON-SU; LEE SEUNG-YOON; LEE CHAE-RIM; CHO SANG-HEE; KIM TAE-HO; LEE HAN-BI; LIM SUN- WOO; SHIN YOO-JIN
权利人:CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION
摘要:The present invention relates to an immunomodulatory therapeutic composition for immunomodulation through the transplantation of induced pluripotent stem cell (iPSC)-derived mitochondria. The iPSC-derived mitochondria according to the present invention overexpress UCP2, and the expression of UCP2 was found to be associated with an immunomodulatory effect. In addition, the administration of iPSC-derived mitochondria was found to enhance mitochondrial function and thereby increase ATP synthesis and mitochondrial membrane potential. In addition, the present invention was found to regulate the expression of autoimmune disease-related immune cells and to increase the synergistic effect of immune cell regulation when used in combination with metformin. In addition, the present invention was found to reduce the activity of autoimmune disease symptoms and inhibit cell expression related to autoimmunity. In addition, treating peripheral blood mononuclear cells with iPSC-derived mitochondria was found to inhibit Th17 expression and increase Treg expression, as well as improve immunomodulation and ameliorate the pathological activity of various immune diseases.

专利号:US-2025277774-A1
优先权日:2024-03-04
标题 :Mixed mode chromatographic packing material
发明人：BAZIULYTE-PAULAVICIENE DOVILE; DAMONSKIS MATAS; WILLIAMS RICHARD THOMAS; JANSONS MARTINÅ
权利人:DIONEX SOFTRON GMBH
摘要:The present invention relates to the field of chromatographic sample separation that includes liquid chromatography and solid phase extraction and, in particular, it relates to material and the synthesis of material for use as a stationary phase in chromatographic sample separation. The invention further relates to uses of the material, in particular in the separation of hydrophilic and hydrophobic peptides, non-glycosylated and N-linked glycosylated peptides, deamidated and oxidized peptides. The invention also relates to chromatographic columns and solid phase extraction columns containing the material as a stationary phase.

专利号:CZ-220494-A3
优先权日:1992-03-09
标题:Composition and methods of identification and synthesis of siallyltransferases