CAS: 51437-00-4; 4-Bromo-1-Fluoro-2-Methylbenzene

上下游产品

CAS号93777-26-5 5-溴-2-氟苯甲醛 | CAS号349-22-4 4-(4-氟-3-甲基苯基)-... | CAS号99725-13-0 5-溴-2-氟苄醇 | CAS号99725-12-9 2-氟-5-溴溴苄 | CAS号135427-08-6 4-氟-3-甲基苯甲醛 | CAS号139911-27-6 4-氟-3-甲基苯硼酸 | CAS号185147-08-4 4-氟-3-甲基苯腈 | CAS号903875-64-9 5-溴-2-氟-3-甲基苯甲醛

5-溴-2-氟苯甲醛置于肼体系中,化学反应生成 5-溴-2-氟甲苯,5-溴吲唑
参考文献:Indazoles: Regioselective Protection And Subsequent Amine Coupling Reactions
标题:Indazoles: Regioselective Protection And Subsequent Amine Coupling Reactions
摘要:Indazoles Are Unselectively Protected Under Strongly Basic Conditions To Give A Mixture At N-1 And N-2. Under Mildly Acidic Conditions,Regioselective Protection At N-2 Takes Place. Thermodynamic Conditions Lead To Regioselective Protection At N-1. This Trend Applies To Various Substituted Indazoles. Protected 5-Bromoindazoles Participate In Buchwald Reactions With A Range Of Amines To Generate Novel Derivative.
DOI:10.1021/jo9006656

专利信息

专利号:US-5736123-A
优先权日:1990-08-09
标 题 :Cocaine receptor binding ligands
发明人：CARROLL FRANK I
权利人:RES TRIANGLE INST
摘要:Novel compounds useful as intermediates in the synthesis of compounds having high affinity for specific cocaine receptors in the brain have the formula ##STR1## wherein R is (CH 2 ) n CH 2 Y, and wherein Y is H or F, X is a pharmaceutically acceptable anion, and n wherein Sn (R 1 , R 2 , R 3 ) is ortho, meta or para and wherein R 1 , R 2 , R 3 are independently alkyl of 1-6 carbon atoms and n is an integer of 0-5.

专利号:US-6136823-A
优先权日:1996-11-28
标题 :Pyridonecarboxylic acid derivatives or salts thereof and drugs containing the same as the active ingredient
发明人：SAKAE NOBUYA; YAZAKI AKIRA; KURAMOTO YASUHIRO; YOSHIDA JIRO; NIINO YOSHIKO; OHSHITA YOSHIHIRO; HIRAO YUZO; HAYASHI NORIHIRO; AMANO HIROTAKA
权利人:WAKUNAGA PHARMA CO LTD
摘要:PCT No. PCT/JP97/04326 Sec. 371 Date May 28, 1999 Sec. 102(e) Date May 28, 1999 PCT Filed Nov. 27, 1997 PCT Pub. No. WO98/23592 PCT Pub. Date Jun. 4, 1998The invention relates to pyridonecarboxylic acid derivatives represented by the general formula (1): wherein R1 is -OH, a carboxy-protecting group or (alkyl)amino group, R2 is H, or -NO2, (protected) amino, (protected) hydroxyl, lower alkyl or lower alkoxyl group, R3 is a halogen atom, H, or -NO2, lower alkyl, lower alkoxyl or amino group, R4 is an azido, (substituted) hydrazino, (substituted) amino, lower alkoxyl or hydroxyl group, R5, R6 and R7 are independently H, -NO2, halogen atom or lower alkyl group, R8 is a -NO2, (substituted) amino, -OH or lower alkoxyl group, A is N or C-R12, in which R12 is H, halogen atom, or (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxyl, lower alkylthio or nitro group, and B is N or C-R13, in which R13 is H or halogen atom, or salts thereof, and medicine comprising such a compound as an active ingredient. The derivatives or the salts thereof exhibit excellent antibacterial action and peroral absorbability, scarcely cause side effects, and are easy of synthesis.

专利号:RU-2189979-C2
优先权日:1996-04-04
标 题 :Diarylmethylidenefuran derivatives, method of their synthesis and pharmaceutical composition based on thereof