CAS: 553-53-7; (3-Pyridylcarbonyl)Hydrazine

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808127-97-1 197079-25-7 112193-41-6

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CAS号93-60-7 烟酸甲酯 | CAS号614-18-6 烟酸乙酯 | CAS号59-67-6 烟酸 | CAS号98-92-0 烟酰胺 | CAS号10400-19-8 烟酰氯 | CAS号110925-43-4 N'-(1-((2S,4S)-... | CAS号1094260-38-4 6-chloro-3-pyri... | CAS号35607-27-3 5-(吡啶-3-基)-4H-1... | CAS号500-22-1 吡啶-3-甲醛 | CAS号141079-04-1 3-[5-[(4-methyl... | CAS号141079-09-6 3-[5-[(4-chloro... | CAS号3690-46-8 5-(3-吡啶基)-1,3,4... | CAS号51362-49-3 2-苯氧基吡啶-3-羰酰氯 | CAS号21398-08-3 3-(5-phenyl-1,3... | CAS号18960-15-1 3-Pyridinecarbo... | CAS号59-67-6 烟酸

烟酰胺置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 6.0H,以85%的收率获得产物3-吡啶甲酰肼
参考文献:1-丙二酰基-1,4-二氢吡啶作为一种新型载体,可以特异性地将药物输送到大脑
标题:1-丙二酰基-1,4-二氢吡啶作为一种新型载体,可以特异性地将药物输送到大脑
摘要:合成了一组1-丙二酰基-1,4-二氢吡啶衍生物,将其作为新型载体系统用于位点特异性和持续向大脑的药物递送.由于存在靠近二氢吡啶的氮的羰基,预期这类载体对空气氧化是稳定的.这些载体体系连接到一组不同的醛上,得到新颖的季吡啶鎓衍生物9A-E,11A-D,13和18A-B.用连二亚硫酸钠还原制备的季吡啶鎓衍生物可得到一组新的1-丙二酰基-1,4-二氢吡啶化学传递系统(cdss)10A-E,12A-D,14和19A-B.对合成的1-丙二酰基-1,4-二氢吡啶cds进行了各种化学和生物学研究,以评估其穿越血脑屏障并被生物氧化为相应的季衍生物的能力.体外氧化研究表明,大多数1-丙二酰基-1,4-二氢吡啶cds可以适当的速率被氧化成其相应的季衍生物.体内研究表明,化合物10C和14能够以可检测的浓度穿过血脑屏障.此外,吡啶鎓季铵中间体9A,图9C,13,18A和其相应的二氢衍生物
DOI:10.1016/j.Bmc.2008.12.051

专利信息

专利号:US-5424432-A
优先权日:1994-05-26
标题:Process for the preparation of imidazolutidine
发明人：FREDENBURGH LAURA E; LARSEN ROBERT D; LIU JI; REAMER ROBERT A; SENANAYAKE CHRIS H; VERHOEVEN THOMAS R
权利人:MERCK & CO INC
摘要:This invention relates to a method for the preparation of a compound of formula I: I a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.

专利号:WO-2022238921-A1
优先权日:2021-05-14
标题 :In-situ synthesis of 3-substituted pyridinium compounds
发明人：GUPTA RAMESHCHANDRA; SRIVASTAVA SANJAY; PATEL MANISH
权利人:TORRENT PHARMACEUTICALS LTD
摘要:Present invention relates to an in-situ and improved process for the preparation of 3-{[2-(methylsulfonyl)hydrazinyl]carbonyl}- 1-[2-oxo-2- (thiophen-2-yl)ethyl]pyridinium salts or salt-cocrystal.

专利号:US-4894380-A
优先权日:1987-04-03
标题:2-mercapto-5-pyridyl-1,3,4-oxadiazoles and 2-mercapto-5-pyridyl-1,3,4-thiadiazoles of the formula I
发明人：NYFELER ROBERT; ECKHARDT WOLFGANG; BERIGER ERNST; KRISTIANSEN ODD
权利人:CIBA GEIGY CORP
摘要:The invention relates to 2-mercapto-5-pyridyl-1,3,4-oxadiazoles and 2-mercapto-5-pyridyl-1,3,4-thiadiazoles of the formula I (I) wherein X is oxygen or sulfur, R' is C1-C3alkyl which is substituted by bromine, fluorine, C1-C3alkoxy or cyano; unsubstituted or halogen-substituted C3-C7alkenyl; unsubstituted or halogen-substituted C4-C7alkynyl, R is C1-C3alkyl, unsubstituted C1-C3alkoxy or C1-C3alkoxy which is substituted by halogen or C1-C3alkoxy; unsubstituted or halogen-substituted C3-C7alkenyl; C3-C7alkynyl, C1-C3alkylthio, halogen, cyano, hydroxy, amino or amino which is substituted by one or two C1-C3alkyl groups; or is aminocarbonyl; and n is 0, 1, 2, 3 or 4, to the preparation of the compounds of formula I and to novel intermediates for the synthesis of these compounds. The compounds of formula I have nematicidal properties. The invention further relates to nematicidal compositions which contain at least one compound of formula I as active component, and to methods of using said compounds and of the compositions containing them for controlling nematodes.

专利号:US-8895747-B2
优先权日:2009-07-27
标 题 :Method and substances for preparation of N-substituted pyridinium compounds
发明人：HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL
权利人:HEINDL DIETER; MAERZ HERIBERT; SCHMIDT AXEL; ROCHE DIAGNOSTICS OPERATIONS
摘要:Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.

专利号:TW-202311253-A
优先权日:2021-05-14
标 题 :In-situ synthesis of 3-substituted pyridinium compounds

专利号:US-2024335420-A1
优先权日:2021-08-02
标题:N-acylhydrazone compounds capable of inhibiting nav 1.7 and/or nav 1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-Acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein substituents R1 to R4 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, useful in the fields of medicinal chemistry, organic synthesis, as well as in the treatment of pain-related disorders.