CAS: 62938-08-3; 1-(Bromomethyl)-3,5-Di-Tert-Butylbenzene

上下游产品

CAS号77387-57-6 3,5-二叔丁基苄醇 | CAS号15181-11-0 3,5-二叔丁基甲苯 | CAS号108-88-3 甲苯 | CAS号16225-26-6 3,5-叔丁基苯甲酸 | CAS号17610-00-3 3,5-双(叔丁基)苯甲醛 | CAS号15181-11-0 3,5-二叔丁基甲苯 | CAS号77387-57-6 3,5-二叔丁基苄醇 | CAS号42288-54-0 3.5-叔丁基苯乙酸 | CAS号62938-09-4 1,3-ditert-buty...

3,5-二叔丁基苄醇置于四溴化碳,三苯基膦体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,以86%的收率获得产物3,5-二叔丁基苄溴
参考文献:甾体硫酸酯酶抑制剂的雌二醇的17α-烷基化衍生物的化学合成和评价
标题:甾体硫酸酯酶抑制剂的雌二醇的17α-烷基化衍生物的化学合成和评价
摘要:类固醇硫酸酯酶(sts)控制着几种正常和恶性组织中循环的类固醇硫酸盐中3-羟基类固醇的水平.因此,已知的活性雌激素和雄激素参与了乳腺癌和前列腺癌等疾病,使sts成为有趣的治疗靶标.在这里,我们描述了使用不同策略的一系列扩展的雌二醇(e2)17α衍生物的化学合成和表征.with-巴比尔反应的一种变体与化学计量的metal金属和催化kagan试剂的形成被用于在雌酮(e1)的17位引入低反应性苄基底物,而杂环底物则被金属化并与羰基或17-环氧乙烷反应e1.体外 对新化合物对sts的抑制能力的评估确定了新的抑制剂,并允许对该e2的17α衍生物家族进行更完整的结构-活性关系研究.
DOI:10.1016/j.Ejmech.2011.06.027

专利信息

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-2008193357-A1
优先权日:2005-07-29
标 题:Method for Enantioselective Synthesis of Phosphorus-Stereogenic Phosphines

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:US-9663482-B2
优先权日:2012-08-03
标 题:Substituted piperazinyl acetohydrazide procaspase-activating compounds
发明人：HERGENROTHER PAUL J; ROTH HOWARD S
权利人:UNIV ILLINOIS
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds are of Formula I n nThe compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:US-9522901-B2
优先权日:2005-05-26
标题:Compositions and methods including cell death inducers and procaspase activation
发明人：HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

专利号:US-11723888-B2
优先权日:2021-12-09
标 题:Polymer conjugated thyrointegrin antagonists
发明人：MOUSA SHAKER A; HAY BRUCE A; KARAKUS OZLEM OZEN
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compounds/compositions, methods of synthesis, and methods of use are provided. The compounds/compositions are directed toward thyrointegrin antagonists directly conjugated to a polymer. The compounds/compositions may further comprise an additional substituent also conjugated to the polymer. The compounds/compositions may demonstrate antiangiogenic effect and efficacy against conditions, particularly cancers.