CAS: 857531-00-1; 4-(4-(1H-Pyrazol-4-yl)Phenyl)-4-(4-Chlorophenyl)Piperidine

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4-(4-溴苯基)-4-(4-氯苯基)哌啶 4-(4-Bromo-Phenyl)-4-(4-Chloro-Phenyl)-Piperidine 857531-01-2

氯苯置于二(三叔丁基膦)钯 Potassium Phosphate,三氯化铝体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 32.0H,反应生成 4-(4-氯苯基)-4-[4-(1H-吡唑-4-基)苯基]哌啶
参考文献:Identification Of Inhibitors Of Protein Kinase B Using Fragment-Based Lead Discovery
标题:Identification Of Inhibitors Of Protein Kinase B Using Fragment-Based Lead Discovery
摘要:Using Fragment-Based Screening Techniques,5-Methyl-4-Phenyl-1H-Pyrazole (Ic50 80 Microm) Was Identified As A Novel,Low Molecular Weight Inhibitor Of Protein Kinase B (Pkb). Herein We Describe The Rapid Elaboration Of Highly Potent And Ligand Efficient Analogues Using A Fragment Growing Approach. Iterative Structure-Based Design Was Supported By Protein-Ligand Structure Determinations Using A Pka-Pkb "Chimera" And A Final Protein-Ligand Structure Of A Lead Compound In Pkbbeta Itself.
DOI:10.1021/jm070091B