CAS: 918898-11-0; 5,7-Dichloropyrido[4,3-D]Pyrimidin-4(3H)-One

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1650574-62-1 2642040-81-9 3018062-74-0

上下游产品

CAS号918898-03-0 4-氨基-2,6-二氯烟酰胺 | CAS号122-51-0 原甲酸三乙酯 | CAS号501907-61-5 N-B°C-4-氨基-2,6-二氯吡啶 | CAS号99-11-6 2,6-二羟基异烟酸 | CAS号5398-44-7 2,6-二氯吡啶-4-甲酸 | CAS号929288-22-2 4-氨基-2,6-二氯烟酸 | CAS号2587-02-2 4-氨基-2,6-二氯吡啶 | CAS号918898-12-1 7-chloro-5-morp...

柠嗪酸置于正丁基锂,四甲基乙二胺,叠氮磷酸二苯酯,N,N-二异丙基乙胺,三氯氧磷体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 22.0H,反应生成 5,7-二氯吡啶并[4,3-D]嘧啶-4(3H)-酮
参考文献: Bicyclic Inhibitors Of Alk[fr] Inhibiteurs Bicycliques De L'Alk
标题: Bicyclic Inhibitors Of Alk[fr] Inhibiteurs Bicycliques De L'Alk
摘要:本发明涉及化合物的公式(1)或药用可接受盐,公式(1)中r1,R2,R3,X,Y,Z,A,B,G1,M和n的定义在说明中.本发明还涉及含有上述化合物的组合物,用于抑制激酶如alk并治疗癌症等疾病的方法.

专利信息

专利号:US-12319691-B2
优先权日:2020-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.