专利号:US-2010099894-A1 优先权日:2006-10-09 标 题 :Method for the Synthesis of Cyclic Acetals by the Reactive Extraction of a Polyol in a Concentrated Solution 发明人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO 权利人:DUBOIS JEAN-LUC; IBORRA CHORNET SARA; VELTY ALEXANDRA I LUCIENNE; CORMA CANOS AVELINO 摘要:A method for the synthesis of cyclic acetals comprises reacting at least one carbonyl-function compound selected from aldehydes, ketones, and/or linear acetals, on a polyol in a concentrated aqueous solution exceeding 20 wt % in a reactor containing an acidic catalyst. The carbonyl-function compound is selected so that the cyclic acetal obtained has a water solubility lower than 20000 mg/kg. During the catalytic reaction for the cyclic acetal synthesis, at least one portion of the organic phase containing the cyclic acetal is separated. The acidic catalysis is either homogeneous when using a water-soluble strong acid, or heterogeneous when using a solid acid such as a resin, a zeolite, or any appropriately acidified solid. The extractive reaction method can be used for obtaining high conversions and selectivity.
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-2007049637-A1 优先权日:2003-11-12 标 题:Process for the synthesis of cationic lipids 发明人:DE FERRA LORENZO; ANIBALDI MAURO; AMMIRATI ETTORE 权利人:CHEMI SPA 摘要:A process for the synthesis of lipid cations having general formula (6): n n nin which: R 1 represents a lipophilic chain; R 2 , R 3 , R 4 , which are identical or different from one another, represent C 1 -C 10 alkyl, C 1 -C 10 alkenyl, or C 1 -C 10 alkynyl radicals, optionally containing hydroxyl, ether, halogen and acyloxy functions, and X − is an oxy-anion or a halide; in which a compound of formula (2), n n nin which R 5 and R 6 , which are identical or different from one another, represent a C 1 -C 5 acyl, a benzyl group or a diol-protective group, is reacted in an alcoholic solvent with from 1 to 6 equivalents of NR 2 R 3 R 4 .
专利号:US-8304540-B2 优先权日:2007-05-18 标题:Process for stereoselective synthesis of lamivudine 发明人:LI JINLIANG; LV FENG 权利人:LI JINLIANG; LV FENG; SHANGHAI DESANO PHARMACEUTICAL HOLDING CO LTD 摘要:The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.
专利号:US-7816546-B2 优先权日:2003-06-30 标 题:Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime 发明人:TUBA ZOLTAN; MAHO SANDOR; KISS JANOS; MAGYARI ENDRENE; TERDY LASZLO 权利人:RICHTER GEDEON VEGYESZET 摘要:The invention relates to a process for the synthesis of d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime (also known as norelgestromin) via acetylation of d-norgestrel at position 17; oximation of the oxo group at position 3 of the obtained d-(17α)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-one; and then hydrolyzing the acetyloxy group at position 17 of the obtained d-(17α)-13-ethyl-17-(acetyloxy)-18,19-dinorpregn-4-ene-20-yn-3-oxime derivative, thereby obtaining norelgestromin.
专利号:US-10385029-B2 优先权日:2014-09-12 标 题:One pot process for synthesis of oxazoline and imidazole compounds from glycerol 发明人:RODE CHANDRASHEKHAR VASANT; PANDYA RAJAN; MANE RASIKA BHARAT 权利人:COUNCIL SCIENT IND RES 摘要:The present invention disclose a single step one pot process for synthesis of oxazoline and imidazole derivatives from glycerol using solid acid metal catalyst with improved yield.
1: Dias CN, Viana AM, Cunha-Silva L, Balula SS. The Role of the Heterogeneous Catalyst to Produce Solketal from Biodiesel Waste: The Key to Achieve Efficiency. Nanomaterials (Basel). 2024 May 9;14(10):828. doi: 10.3390/nano14100828. 2: Dias CN, Santos-Vieira ICMS, Gomes CR, Mirante F, Balula SS. Heteropolyacids@Silica Heterogeneous Catalysts to Produce Solketal from Glycerol Acetalization. Nanomaterials (Basel). 2024 Apr 23;14(9):733. doi: 10.3390/nano14090733. 3: Julião D, Mirante F, Balula SS. Easy and Fast Production of Solketal from Glycerol Acetalization via Heteropolyacids. Molecules. 2022 Oct 4;27(19):6573. doi: 10.3390/molecules27196573.
合成参考文献
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