CAS: 111-16-0; Heptanedioic Acid

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2050-20-6 629-30-1 1732-08-7

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CAS号502-42-1 环庚酮 | CAS号628-92-2 环庚烯 | CAS号646-20-8 1,5-二氰基戊烷 | CAS号13553-19-0 trans-cyclohept... | CAS号4747-15-3 Β-苯乙烯甲醚 | CAS号88356-04-1 2-benzylidenecy... | CAS号22081-48-7 cyclohepten-1-y... | CAS号502-41-0 环庚醇 | CAS号13154-27-3 2-nitr°Cyclohep... | CAS号10521-07-0 2,8-Ox°Canedione | CAS号41302-34-5 2-氧环己烷羧酸甲酯 | CAS号362670-19-7 7-(4-BIPHENYL)-... | CAS号33018-91-6 庚二酸氢乙酯 | CAS号4549-31-9 1,7-二溴庚烷 | CAS号628-76-2 1,5-二氯戊烷 | CAS号4224-62-8 6-氯己酸 | CAS号108-94-1 环己酮 | CAS号142-62-1 正己酸 | CAS号462-94-2 1,5-二氨基戊烷

环庚烷置于n-羟基邻苯二甲酰亚胺,硝酸,三氟乙酸体系中,20.0 °C,101.33 Kpa 条件下,反应 18.0H,以41%的收率获得庚二酸
参考文献:在常温常压下有机合成催化环己烷直接氧化合成己二酸
标题:在常温常压下有机合成催化环己烷直接氧化合成己二酸
摘要:据报道,由环己烷生产己二酸的直接无金属方法.在hno 3 / Tfa存在下使用n-羟基邻苯二甲酰亚胺(nhpi)作为催化剂能够通过简单的方法在环境温度和压力下将环己烷直接氧化以产生己二酸.该反应通过将环己烷最初氧化为环己酮肟和环己酮,然后将这些中间体第二次氧化为己二酸而进行.Nhpi在两个氧化步骤中都起着至关重要的作用,以实现己二酸的高收率和选择性.
Doi:10.1021/acs.Oprd.8B00196

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-4895922-A
优先权日:1988-05-05
标 题 :Low temperature synthesis of polyesteramides
发明人：OGATA NAOYA
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention disclosed a process for the synthesis of polyesteramides. By utilizing the phosphorus containing catalyst systems of the present invention, such polyesteramides can be synthesized at relatively low temperatures. The present invention specifically discloses a process for the synthesis of a polyesteramide which comprises polymerizing at least one diamine, at least one diol, and at least one dicarboxylic acid in the presence of (1) at least one acid acceptor; (2) at least one halogenated organic compound; and (3) at least one phosphorus containing compound selected from the group consisting of (a) triphenylphosphine, (b) triphenylphosphine oxide, (c) triphenylphosphine sulfide, (d) polymeric agents having pendant diphenylphosphine groups, (e) silicon-phosphorus compositions which contain at least one divalent oxygen atom which is bonded directly to a tetravalent silicon atom and a trivalent or pentavalent phosphorus atom; (f) compounds with the structural formula (C 6 H 5 ) 3 P=N-R, wherein R is a hydrogen atom or an alkyl group containing from 1 to 10 carbon atoms; and (g) compounds with the structural formula (C 6 H 5 )PR 1 R 2 wherein R 1 and R 2 can be the same or different, wherein R 1 is selected from the group consisting of alkyl groups containing from 1 to 10 carbon atoms and phenyl groups, and wherein R 2 is an alkyl group containing from 1 to 10 carbon atoms.

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:US-9957355-B2
优先权日:2013-06-12
标 题 :Device and method for synthesis of a polymer under separation of a gaseous substance
发明人：ZHU NING; STAMMER ACHIM; CLAUSS JOACHIM; KORY GAD
权利人:BASF SE
摘要:The invention relates to a device for synthesis of a polymer under separation of a gaseous substance. Said device comprises a reaction chamber ( 1 ), which has a top section ( 11 ), a middle section ( 12 ) and a bottom section ( 13 ), an inlet opening ( 2 ) which is arranged in the middle section ( 12 ), a first outlet opening ( 3 ) which is arranged in the bottom section ( 13 ), a second outlet opening ( 4 ) which is arranged in the top section ( 11 ), a first return opening ( 51 ), which is arranged in the bottom section ( 13 ), a second outlet opening ( 52 ), which is arranged under the top section ( 11 ), a distribution device ( 6 ), which is arranged between the top section ( 11 ) and the middle section ( 12 ), and a removal device ( 7 ) which is arranged to be movable along the top section ( 11 ). The invention further relates to a method for synthesis of a polymer which can be carried out in said device.

专利号:US-7241900-B2
优先权日:2002-02-12
标题 :Synthesis of indole thiazole compounds as ligands for the Ah receptor
发明人：DELUCA HECTOR F; GRZYWACZ PAWEL K; SICINSKI RAFAL R
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of synthesizing aromatic ketone compositions of formula I comprising the step of introducing a double bond into the 5 membered ring of the 4,5-dihydro-1,3-azoles moiety of formula II is disclosed. A method of synthesizing aromatic ketone compositions of formula I comprising the step of ring synthesis of the tetrahydro-1,3-azoles of formula XI is also disclosed.

专利号:US-2024383940-A1
优先权日:2021-03-31
标题 :Synthesis of trinucleotide and tetranucleotide caps for mrna production
发明人：ENDO ATSUSHI
权利人:MODERNA TX INC
摘要:Provided herein are methods of making trinucleotides and tetranucleotides for use as 5′ mRNA caps. The methods utilize a novel “top-down†strategy and provide for synthesis of oligonucleotides with higher yields and increased efficiency compared to traditional methods. A key step of the methods disclosed, herein can also be adapted to utilize a “one-pot†approach, resulting in an increase in the yield of the final oligonucleotide product.