CAS: 1120-99-6; 1,2,4-Triazin-3-Amine

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290-38-0 89124-32-3

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CAS号2582-30-1 氨基胍碳酸氢盐 | CAS号2200-97-7 氨基胍碳酸氢盐 | CAS号290-38-0 [1,2,4]三嗪 | CAS号69249-22-5 3-氨基-6-溴-1,2,4-三嗪 | CAS号104405-58-5 1,2,4-Triazine-...

草酸醛,氨基胍碳酸氢盐置于盐酸,Potassium Hydroxide体系中,用 水 用作溶剂,化学反应 2.0H,以17%的收率获得1,2,4-三嗪-3-胺
参考文献:1,2,4-三嗪与双环壬炔的应变促进反应
标题:1,2,4-三嗪与双环壬炔的应变促进反应
摘要:最快的生物正交反应是1,2,4,5-四嗪和应变双亲物(如双环壬炔)之间的应变促进的逆电子需求diels-Alder环加成反应(spiedac).但是,1,2,4,5-四嗪的合成很复杂,可能涉及挥发性试剂.1,2,4-三嗪还可以在高温下与无环和无应变的亲双烯体进行环加成反应,但尚未描述它们与应变炔烃的反应.我们推测1,2,4-三嗪会在低温下与炔烃反应,因此为体外或体内标记实验中使用的四嗪环加成反应提供了另一种选择.我们描述了1,2的合成 4-Triazin-3-Ylalanine衍生物与芴基甲基氧羰基(fmoc)的肽合成策略完全兼容,并在37oc的条件下证明了其与应变双环壬炔的反应速率与叠氮化物与相同底物的反应相当.合成三嗪基丙氨酸的途径很容易适应其他探针分子的后期功能化,因此1,2,4-三嗪-Spiedac有潜力替代四嗪环加成,用于细胞和生化研究.
Doi:10.1002/chem.201502397

专利信息

专利号:US-11472779-B1
优先权日:2022-05-13
标 题 :One-pot synthesis of hydrogen-bonded organic frameworks
发明人：KHAN MOHD YUSUF; KHAN ABUZAR; HELAL AASIF; YAMANI ZAIN H
权利人:UNIV KING FAHD PET & MINERALS
摘要:A hydrogen-bonded organic framework (HOF) and a method of making the HOF. The HOF has at least one amine substituted organic linker and at least one carboxylic acid-based organic linker. The HOF is prepared by dissolving the linkers separately in water and mixing the aqueous solutions, without using any organic solvents, additional catalysts, or any other reagents.

专利号:US-6582952-B1
优先权日:1997-09-22
标 题:Method for eliminating a nitrogenated heterocyclic, or aromatic, compound in an effluent
发明人：LE CAMPION LAURENCE; OUAZZANI JAMAL
权利人:CENTRE NAT RECH SCIENT; COMMISSARIAT ENERGIE ATOMIQUE
摘要:This invention relates to a method for the removal of a nitrogen containing heterocyclic or aromatic compound, comprising at least one nitro group, in an effluent by the conversion of said, at least one nitro group into an amine group by means of a reducing agent. The reducing agent can be hydrogen in the presence of Pd/C or a micro-organism. n This invention also relates to a method for the synthesis of 5-amino-1,2,4-triazole-3-one from 5-nitro-1,2,4-triazole-3-one by said method of conversion, that allows one to achieve synthesis yields greater than 80%. n This invention also relates to a colony of the type Bacillus licheniformis capable of converting one or more nitro groups of nitrogen containing heterocyclic compounds into one or more amine groups. This colony has been filed in the CNCM, held by the Pasteur Institute, under the number I-1915.

专利号:US-10000487-B2
优先权日:2015-11-20
标 题 :Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
发明人：SPRENGELER PAUL A; REICH SEIGFRIED H; WEBBER STEPHEN E; ERNST JUSTIN T
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. n nFor Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:WO-2022126388-A1
优先权日:2020-12-15
标 题:Method for synthesizing 5-bromo-1h-3-amino-1,2,4-triazole
发明人：YE WEIPING; PHILLIS ANDREW TOROA; ZHOU ZHANGTAO; XIE YANGYIN; Xi Lingang; XIANG WEI
权利人:SHENZHEN HWAGEN PHARMACEUTICAL CO LTD
摘要:A method for synthesizing 5-bromo-1H-3-amino-1,2,4-triazole. The method has a route as (aa), in which a mixture of sodium bromate and sodium bromide is employed to serve as a brominated reagent; and a reaction route as (bb). The synthesis of 5-bromo-1H-3-amino-1,2,4-triazole per the method has a novel process route and a total molar yield of greater than 50%. The reaction is highly safe and easy to industrialize, and has a high yield, inexpensive costs, and relatively mild reaction conditions.