CAS: 171197-80-1; 2-Fluoro-5-Iodopyridine

相似化合物

685517-67-3 113975-22-7 22282-70-8

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CAS号20511-12-0 2-氨基-5-碘吡啶 | CAS号504-29-0 2-氨基吡啶 | CAS号1034467-80-5 5-环丙基-2-氟吡啶 | CAS号351019-18-6 6-氟-3-吡啶硼酸 | CAS号444120-95-0 2-氟吡啶-5-硼酸频哪醇酯 | CAS号853909-08-7 5-炔-2-氟吡啶 | CAS号663955-59-7 5-乙炔-2-甲氧基吡啶 | CAS号1133879-66-9 5-乙烯基-2-氟吡啶 | CAS号444120-93-8 2-氟-5-(4-甲氧基苯基)吡啶

2-氯-5-碘吡啶置于四甲基氟化铵体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,以87%的收率获得2-氟-5-碘吡啶
参考文献:室温s N Ar氟化的无水四甲基氟化铵
标题:室温s N Ar氟化的无水四甲基氟化铵
摘要:本文介绍了使用无水四甲基氟化铵(nme 4 F)在室温下对芳基卤化物和硝基芳烃进行s N Ar氟化.该试剂在温和的条件下(通常在室温下)有效地将芳基-X(x = Cl,Br,I,No 2,Otf)转化为芳基-F.该反应的底物包括缺电子的杂芳族化合物(22个实例)和芳烃(5个实例).反应的相对速率随x以及底物的结构而变化.但是,一般而言,带有x = No 2的基材或br反应最快.在所检查的所有情况下,这些反应的收率均与在升高的温度(即,更传统的卤代氟化条件)下使用csf所获得的收率相当或更好.反应还提供了可比较的产量,规模从100 Mg到10 G不等.进行了成本分析,结果表明,使用nme 4 F进行氟化处理通常比使用csf进行氟化处理更具成本效益.
Doi:10.1021/acs.Joc.5B02075

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:WO-2024185814-A1
优先权日:2023-03-06
标题:Method for producing aryl compound containing tritylsulfanyl group
发明人：OKAZOE TAKASHI; NOZAKI KYOKO; GATZENMEIER Tim; LIU YUE
权利人:AGC INC; UNIV TOKYO
摘要:The present invention provides: a substrate for achieving the highly efficient synthesis of an aryl compound containing a tritylsulfanyl group; a method for producing a compound containing an SF 5 group using the substrate; and others. The present invention is a method for producing an aryl compound containing a tritylsulfanyl group, the method comprising thiotritylating a halogenated aryl compound represented by general formula (1) [wherein A 1 represents an aryl group that may have a substituent or a heteroaryl group that may have a substituent; and X represents a halogen atom] using [(triphenylmethyl)sulfanyl]potassium or [(triphenylmethyl)sulfanyl]sodium to produce an aryl compound containing a tritylsulfanyl group, the aryl compound being represented by general formula (2) [wherein A 1 is the same as A 1 in general formula (1); and Ph represents a phenyl group].

专利号:JP-2014521677-A
优先权日:2011-08-01
标 题:Precursor compounds for radioactive synthesis of [18F] norchloro-fluoro-homoepibatidine

专利号:CN-114014790-A
优先权日:2021-12-03
标 题 :Synthesis method of selenide/thioether compound and synthesized compound