CAS: 31112-62-6; 3-Acetamido-2,4,6-Triiodo-5-(N-Methylacetamido)-N-((2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-1-Oxohexan-2-yl)Benzamide

上下游产品

N-Methyl-3,5-diacetamido-2,4,6-triiodobenzoyl chloride D-glucosamine hydr°Chloride pyrographite

N-Methyl-3,5-Diacetamido-2,4,6-Triiodobenzoyl Chloride,D-Glucosamine Hydrochloride,甲烷置于potassium Carbonate体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 用作溶剂,化学反应生成甲泛葡胺
参考文献:Amido Derivatives Of 2,4,6-Triiodobenzoic Acids Containing At Least One
标题:Amido Derivatives Of 2,4,6-Triiodobenzoic Acids Containing At Least One
摘要:这项发明涉及新型x射线造影剂,特别用于脑脊液腔,包括携带至少一个n-键合的二次或三次酰胺基团并且分子中至少有两个羟基和至少一个碘原子的非离子烷醇.特别有用的化合物包括至少有两个羟基的n-羟基烷基碘烷磺酰胺,携带氨基甲酰,酰胺基或酰氨基甲基取代基并且分子中至少有两个羟基和至少一个n-羟基的三碘苯和四碘苯.特别优选的化合物包括2,4,6-三碘苯酰胺,它们可能在3-和/或5-位置上被各种基团取代.这些化合物都表现出明显低的毒性,其中一些化合物具有非常高的水溶性水平.

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-11718864-B2
优先权日:2015-09-23
标 题 :Cells and method of cell culture
发明人：HILLER GREGORY WALTER; MITCHELL JEFFREY JOSEPH; MULUKUTLA BHANU CHANDRA; PEGMAN PAMELA MARY
权利人:PFIZER
摘要:The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.

专利号:US-9238615-B2
优先权日:2009-04-21
标 题 :Process for the iodination of aromatic compounds
发明人：CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA
权利人:CITTERIO ATTILIO; LATTUADA LUCIANO; LEONARDI GABRIELLA; UGGERI FULVIO; VIGNALE EVELIN; VISIGALLI MASSIMO; FERRIGATO AURELIA; MELI GABRIELE; FRETTA ROBERTA; MAZZON ROBERTA; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

专利号:US-9193659-B2
优先权日:2008-02-20
标 题 :Process for the iodination of aromatic compounds
发明人：GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO
权利人:GIOVENZANA GIOVANNI BATTISTA; CAVALLOTTI CAMILLA; LATTUADA LUCIANO; UGGERI FULVIO; BRACCO IMAGING SPA
摘要:The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).

专利号:US-2011104052-A1
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres
发明人：BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
权利人:UNIV JOHNS HOPKINS
摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.