CAS: 54-42-2; 1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-5-Iodopyrimidine-2,4(1H,3H)-Dione

相似化合物

105784-83-6 1024-99-3 951-78-0

上下游产品

CAS号951-78-0 2’-脱氧尿苷 | CAS号696-07-1 5-碘尿嘧啶 | CAS号1956-30-5 3',5'-双乙酰基-5-碘-脱氧尿苷 | CAS号65505-76-2 5-chloromercuri... | CAS号51592-06-4 1,3,4,6-四氯-3α,6... | CAS号50-89-5 beta-胸苷 | CAS号13030-62-1 3',5'-二-O-乙酰基-2... | CAS号146629-34-7 5-(TriMethylsta... | CAS号951-78-0 2’-脱氧尿苷 | CAS号50-90-8 CldU(5-氯-2'-脱氧尿苷) | CAS号144989-71-9 1-[(2R,4S,5R)-5... | CAS号92233-50-6 Aids186752 | CAS号37972-24-0 2-乙炔基嘧啶 | CAS号1956-30-5 3',5'-双乙酰基-5-碘-脱氧尿苷 | CAS号215668-76-1 5-dodec-1-ynyl-... | CAS号36792-88-8 2-Deoxy-β-D-rib... | CAS号696-07-1 5-碘尿嘧啶 | CAS号66-22-8 尿嘧啶

[(2R,3S,5R)-3-(4-Chlorobenzoyl)Oxy-5-(5-Iodo-2,4-Dioxopyrimidin-1-yl)Oxolan-2-Yl]Methyl 4-Chlorobenzoate置于氨体系中,用 甲醇 作为反应溶剂,化学反应 16.0H,反应生成 碘苷
参考文献:5-取代的2'-脱氧尿苷异头体的立体选择性合成
标题:5-取代的2'-脱氧尿苷异头体的立体选择性合成
摘要:研究了5-取代的2,4-双(三甲基甲硅烷氧基)嘧啶与3,5-双(Op-氯苯甲酰基)-2-脱氧-α-D-呋喃核糖基氯的取代反应.在对硝基苯酚的存在下,β端基异构体立体选择性地形成,而有机碱的加入导致α端基异构体的立体选择性形成.反应的立体选择性取决于二甲硅烷基嘧啶的 5 位取代基,添加剂和每种试剂的浓度.5-取代的2'-脱氧-尿苷的α和β异头通过5-取代3',5'-二-O-(对-氯苯甲酰基)-2'-脱氧尿苷的α和β异头脱酰化合成.
DOI:10.1246/bcsj.60.2073

专利信息

专利号:US-7026114-B1
优先权日:1995-09-13
标 题:Methods and compositions for monitoring polymer array synthesis
发明人：BARONE ANTHONY D; MC GALL GLENN H; CHAI EVELYN; NGO NAM QUOC
权利人:AFFYMETRIX INC
摘要:VLSIPSâ„¢ manufacturing processes are of increasing commercial importance. The present invention provides methods and compositions for monitoring the efficiency and quality of polymer synthesis in VLSIPSâ„¢ arrays. Methods for monitoring polymer synthesis in an array on a substrate are provided. Monoisomeric labels for the labeling of synthetic polymer arrays are provided. Methods and compositions for post-synthetically labeling polymers in polymer arrays are also provided.

专利号:US-2008261823-A1
优先权日:2004-12-10
标 题 :Fluorescent Nucleoside Analogs That Mimic Naturally Occurring Nucleosides
发明人：TOR YITZHAK
权利人:TOR YITZHAK
摘要:The present invention provides fluorescent nucleoside analogs with conjugated membered heterocycles, including furan and thiophene. The fluorescent nucleoside analogs maintain structural similarity to naturally occurring nucleoside bases, mimicking shape, size, hybridization, and recognition properties. Incorporation of the fluorescent cyclic compounds confers specific photophysical characteristics including a bathochromic (red) shift of the absorption spectrum to minimize absorption overlap with naturally occurring nucleoside bases, and a shift to the long emission wavelength in the visible range. The invention also provides for various methods of synthesizing the fluorescent nucleoside analogs and incorporating the fluorescent analogs in DNA, RNA, or oligomer synthesis. Further, methods of detecting the fluorescent nucleoside analogs in an oligonucleotide or oligomer are provided. The subject compounds are useful as probes in the study of the structure and dynamics of nucleic acids and their complexes with proteins.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.

专利号:US-9688980-B2
优先权日:2001-06-20
标 题 :Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; FRANCH THOMAS; SAMS CHRISTIAN KLARNER; OLSEN EVA KAMPMANN; SLOK FRANK ABILGAARD; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; HYLDTOFT LENE; NORREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRODER; THISTED THOMAS; FRESKGARD PER-OLA; HOLTMANN ANETTE
权利人:NUEVOLUTION AS; NUEVOLUTION
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.