CAS: 54897-59-5; 2,3-Diaminopropanoic Acid Hydrochloride

该化合物是氨酸丙胺盐的盐酸盐,其特征是白到白,在水中可溶解,适合各种生化应用;化合物的特征是氨基(-NH2),一个碳箱基(-COH)组,以及一组甲基(-CH3)的副链,该链将它归类为非极酸,脂氨基酸;作为Zwitter,它拥有生理pH的正和负电荷,有助于其在蛋白合成和新陈代谢中的作用;阿兰因参与凝胶的产生,并成为能源生产的关键亚基质;盐酸形式增强其稳定性和溶解性,使其在制药配方和营养补充中有用;此外,人们普遍认为,它对于消费来说是安全的,尽管具体的剂量和使用应当以专业建议为指导.

结构式图片

相似化合物

18635-45-5 6018-56-0 122235-70-5

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

(S)-3-[(phenylmethyloxy)amino]-N-[(phenylmethyloxy)carbonyl]alanine 3-Amino-2-benzoylamino-propionic acid methyl ester methyl (R)-(-)-3-acetamido-2-aminopropanoatemethyl 2,3-diaminopropanoate dihydr°Chloride 2,3-bis(tert-butoxycarbonyl amino)propanoic acid butyl DL-2,3-diaminopropionate dihydr°Chloride 5,6-bis(4-chlorophenyl)-pyrazine-2-carboxylic acid

合成工艺路线路线简述

    Methyl 3-Amino-2-Benzamidopropanoate置于盐酸体系中,用 甲醇 作为反应溶剂,化学反应 12.0H,反应生成 Dl-2,3-二胺基丙酸盐酸盐
    参考文献:Burgess,Vicky A.; Easton,Christopher J.,Australian Journal Of Chemistry,1988,Vol. 41,# 7,P. 1063-1070
    标题:Burgess,Vicky A.; Easton,Christopher J.,Australian Journal Of Chemistry,1988,Vol. 41,# 7,P. 1063-1070

    海关参考信息

    专利信息


    专利号:US-2007122842-A1
    优先权日:2005-11-30
    标题 :Massively parallel synthesis of proteinaceous biomolecules
    发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
    权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
    摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

    专利号:US-2007122841-A1
    优先权日:2005-11-30
    标题:Massively parallel synthesis of proteinaceous biomolecules
    发明人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
    权利人:RAJASEKARAN JOHN J; TIWARI GUNJAN; CABEZAS EDELMIRA; FIDANZA JACQUELINE A; SUNDARARAJAN NARAYAN
    摘要:Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.

    专利号:US-10577391-B2
    优先权日:2014-02-21
    标题 :Selective photoactivation of amino acids for single step peptide coupling
    发明人:JAYARAMAN VASANTH
    权利人:VIBRANT HOLDINGS LLC
    摘要:Disclosed herein are formulations, substrates, and arrays for amino acid and peptide synthesis on microarrays. In certain embodiments, methods for manufacturing and using the formulations, substrates, and arrays including one-step coupling, e.g., for synthesis of peptides in a C→N orientation are disclosed. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.

    专利号:US-11612556-B2
    优先权日:2014-12-16
    标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
    发明人:PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
    权利人:SEDERMA SA
    摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

    专利号:US-8546533-B2
    优先权日:2008-08-29
    标 题:Pipecolic linker and its use for chemistry on solid support
    发明人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
    权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
    摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

    专利号:WO-03068806-A1
    优先权日:2002-02-14
    标 题 :Solid phase peptide synthesis on silica
    发明人:GROARKE MICHELLE
    权利人:JOHNSON MATTHEY PLC; GROARKE MICHELLE
    摘要:A method for peptide synthesis is described, comprising steps of forming an organofunctional silica by reaction of an alkyl silicate, an organofunctional silane and water, optionally in the presence of a template compound; removing the template compound if present; reacting said organofunctional silica with a first protected amino acid to produce a tethered protected amino acid; deprotecting the tethered protected amino acid; reacting at least one further protected amino acid with said tethered deprotected amino acid to form a tethered peptide, and removing the peptide from the organofunctional silica. Preferably, prior to reaction of the first protected amino acid, the organofunctional silica is reacted with at least one linking compound to form a linker-modified organofunctional silica with which the first protected amino acid is reacted. A method for preparing an organfunctional silica by the co-hydrolysis of an alkyl silicate and an organofunctional silane is depicted below. The wavy line represents the silicon atom on or within the resulting silica material formula (I). A reaction of a protected amino acid with an organofunctional silica to provide a tethered protected amino acid is depicted below formula (II).
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    主要参考文献

    [参考文献]: A N Chulin, Et Al. Synthesis Of 9-Membered Dilactams Derived From 1,3-Diaminopropionic And Glutamic Acids. J Pept Res. 2004 Mar;63(3):235-40.
    [参考文献]: Fumiko Fujisaki, Et Al. A Conventional Route For The Synthesis Of New Oxazolidin-2-One Derivatives With Beta-Aminoalanines. Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1238-41.
    [参考文献]: Giovanni N Roviello, Et Al. Synthesis Of A Diaminopropanoic Acid-Based Nucleoamino Acid And Assembly Of Cationic Nucleopeptides For Biomedical Applications. Amino Acids. 2012 Dec;43(6):2537-43.
    [参考文献]: J N Kalyani, Et Al. Functional Analysis Of The Genes Encoding Diaminopropionate Ammonia Lyase In Escherichia Coli And Salmonella Enterica Serovar Typhimurium. J Bacteriol. 2012 Oct;194(20):5604-12.
    [参考文献]: Kamila Stokowa, Et Al. Capreomycin--A Polypeptide Antitubercular Antibiotic With Unusual Binding Properties Toward Copper(Ii). J Inorg Biochem. 2012 Jan;106(1):111-6.

    合成参考文献


    参考文献:10.1007/bf02555250
    摘要:Aoba T, Moreno EC. The enamel fluid in the early secretory stage of porcine amelogenesis: chemical composition and saturation with respect to enamel mineral. Calcif Tissue Int. 1987 Aug;41(2):86–94. doi: 10.1007/bf02555250.
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