Geranyldehydrolinaool置于lindlar'S Catalyst 喹啉,氢气体系中,用 环己烷 作为反应溶剂,化学反应生成 替普瑞酮 参考文献:Weichet,J. Et Al.,Collection Of Czechoslovak Chemical Communications,1960,Vol. 25,P. 1914-1921 标题:Weichet,J. Et Al.,Collection Of Czechoslovak Chemical Communications,1960,Vol. 25,P. 1914-1921
专利号:US-9981935-B2 优先权日:2013-07-05 标 题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids 发明人:MEDLOCK JONATHAN ALAN; LETINOIS ULLA; NETSCHER THOMAS; BONRATH WERNER 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of a specific type and of at least one Bransted acid or in the presence a specific chiral compound having a Bransted acid functional group in the molecule.
专利号:US-9815809-B2 优先权日:2013-07-05 标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols 发明人:LETINOIS ULLA; NETSCHER THOMAS 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.
专利号:US-9809565-B2 优先权日:2013-07-05 标 题 :Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of ureas or thioureas 发明人:LETINOIS ULLA; NETSCHER THOMAS; ACKERMANN STEPHAN 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.
专利号:US-2004249219-A1 优先权日:2000-07-05 标题 :Method of making teprenone 发明人:SAUCY GABRIEL G 摘要:The invention is directed to an efficient and economical method of making teprenone. Teprenone is synthesized by converting geranylgeraniol to teprenone by a novel route. The method of synthesis can begin with geranylgeraniol obtained from a biological source such as fermentation of a microorganism capable of producing geranylgeranyl or enzymatic synthesis in a cell free system to produce predominantly the 5E isomer of teprenone. The chemical synthesis proceeds with retention of configuration such that the teprenone produced has the isomeric configuration of the geranylgeraniol starting material.
专利号:WO-2014018862-A1 优先权日:2012-07-27 标 题 :Pharmaceutical compositions comprising a heat shock protein inhibitor and a; purine de novo synthesis inhibitor for treating rheumatoid arthritis or cancer 发明人:FANG YE 权利人:CORNING INC; FANG YE 摘要:A pharmaceutical composition including an effective amount of the combination of: an heat shock protein (HSP) inhibitor, and a purine de novo biosynthesis inhibitor, or a pharmaceutically acceptable salt thereof. Also disclosed is a method of treating rheumatoid arthritis or cancer including administering an effective amount of the above mentioned pharmaceutical composition to a patient in need of such treatment, as defined herein.
专利号:US-3939202-A 优先权日:1973-01-31 标题:Process for preparing polyene compounds 发明人:MATSUI MASANAO; KITAMURA SEIICHI; MORIOKA MASAHIRO 权利人:TEIKOKU CHEM IND CO LTD 摘要:Polyene compounds of the formula: ##EQU1## wherein R' is protected or unprotected hydroxyl or a group of the formula: ##EQU2## (in which R' and R'' are each carboxyl or a group convertible into carboxyl on hydrolysis), m is a positive integer and n is 0 or a positive integer, which are useful as intermediates in the synthesis of coenzyme Q, can be produced advantageously through a step for the dehydration of a compound of the formula: ##EQU3## wherein R', m and n are each as defined above.
参考文献:10.1016/j.ejmech.2017.07.043 摘要:Maruta H, Ahn M. From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy. European Journal of Medicinal Chemistry. 2017 Dec;142():229–43. doi: 10.1016/j.ejmech.2017.07.043.