CAS: 78686-79-0; Methyl 5-Bromo-2-Chloronicotinate

相似化合物

228251-24-9 29241-65-4 742100-75-0

上下游产品

diazomethane 5-bromo-2-chloronicotinic acid methanol 5-bromo-2-chloro-pyridine-3-carbonyl chloride-1,3-butadiyne1,4-bis4-(tert-butoxycarbonyl)phenyl-1,3-butadiyne (5-bromo-2-chloro-pyridin-3-yl)-methanol methyl 5-bromo-2-methoxy-3-pyridinecarboxylate methyl 5-bromo-2-fluoropyridine-3-carboxylate

甲醇置于n,N-二甲基甲酰胺 氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 3.0H,以95%的收率获得产物5-溴-2-氯烟酸甲酯
参考文献:Met Kinase Inhibitors
标题:Met Kinase Inhibitors
摘要:本发明涉及具有以下化学式i或ii的化合物:包括其盐,并且使用它们用于治疗癌症的方法.

专利信息

专利号:WO-2023081730-A1
优先权日:2021-11-03
标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
发明人：ELZEIN ELFATIH; LIU JIWEN
权利人:TEON THERAPEUTICS INC
摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

专利号:US-9815842-B2
优先权日:2014-05-28
标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
发明人：SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS
权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG
摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.

专利号:US-9682966-B2
优先权日:2012-08-16
标 题 :Kappa opioid ligands
发明人：ROBERTS EDWARD; GUERRERO MIGUEL A; URBANO MARIANGELA; ROSEN HUGH
权利人:SCRIPPS RESEARCH INST
摘要:The invention provides novel ligands of Kappa (κ) opioid receptors, such as can be used to modulate a Kappa opioid receptor. Methods of synthesis and methods of use are also provided. Compounds of the invention can be used therapeutically in the treatment of dissociative disorders or pain, or to provide neuroprotection, or to induce diuresis, or to modulate the immune system, or for treatment of one or more of an affective disorders comprising depression or stress/anxiety; an addictive disorder; alcoholism, epilepsy; a cognition deficiency; schizophrenia; Alzheimer's disease; or pain.