CAS: 875781-43-4; 2-Bromo-5H-Pyrrolo[2,3-B]Pyrazine

相似化合物

1201186-54-0 875781-44-5 1150617-58-5

5-溴-3-乙炔吡嗪-2-胺 以 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 16.5H,反应生成 5-溴-4,7-二氮杂吲哚
参考文献:吲哚或氮杂苯并吡咯类化合物的合成方法
标题:吲哚或氮杂苯并吡咯类化合物的合成方法
摘要:本发明涉及一种吲哚或氮杂苯并吡咯类化合物的合成方法,包括如下步骤:将化合物a与二取代胺在溶剂中进行成环反应;所述二取代胺的结构通式为nh(R2)2,R2分别独立选自选自c1~c6烷基,C1~c6烷基羟基,C1~c6烷基‑o‑c1~c6烷基,C1~c6烷基‑nh‑c1~c6烷基或c1~c6烷基胺基,两个r2互相连接成环或不成环.上述吲哚或氮杂苯并吡咯类化合物的合成方法采用特定结构通式的二取代胺类化合物与中间体的端炔基进行加成反应,改变了端炔基的刚性结构,变成了烯基胺的构型,由此在温和的反应条件下,实现吲哚或氮杂苯并吡咯类化合物中吡咯基团的合环,且副反应少,产物收率高,从源头上降低了产品的生产成本.

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2013072495-A1
优先权日:2010-05-14
标 题 :Fused bicyclic kinase inhibitors
发明人：LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G
权利人:LI AN-HU; MULVIHILL MARK J; STEINIG ARNO G; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula I, as shown below and defined herein: pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as but not limited to tumors driven at least in part by at least one of RON, MET, IR, IGF-1R, or ALK. This Abstract is not limiting of the invention.

专利号:US-9834551-B2
优先权日:2013-04-18
标 题 :Substituted pyrrolo[2,3-b]pyrazines and substituted pyrazolo[3,4-b]pyridines as ITK and JAK kinase inhibitors
发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANGIREDDY PARAMAREDDY; APPALANENI RAJENDRA P
权利人:ARRIEN PHARMACEUTICALS LLC
摘要:The present invention relates to compounds described by Formula I: n nsalts thereof, their synthesis, and their use as ITK and JAK3 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and or disorders such disease associated with abnormal cell growth such as autoimmune, inflammation, rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis, ulcerative colitis, psoriatic arthritis, psoriasis, Crohn's, metabolic and cancer diseases. The present invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions and processes for preparing the compounds of the invention.

专利号:CN-119119058-A
优先权日:2023-06-13
标题:Synthesis method of Marpatinib, intermediate and preparation method of intermediate