CAS: 13958-98-0; 3-Bromo-4-Cyanopyridine

相似化合物

13959-02-9 70201-43-3 13958-99-1

上下游产品

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4-氰基吡啶置于四溴化碳体系中,用 四氢呋喃 用作溶剂,化学反应 1.5H,反应生成3-溴-4-氰基吡啶
参考文献:Synthesis Of Ortho-Substituted Cyanopyridines Through Lithio Intermediate Trapping
标题:Synthesis Of Ortho-Substituted Cyanopyridines Through Lithio Intermediate Trapping
摘要:Ortholithiation Of 4-Cyanopyridine Using 2,2,6,6-Tetramethylpiperidide (Litmp) And Trapping The Lithio Intermediate With Electrophiles Represents An Efficient And Straightforward Access To Ortho-Substituted-4-Cyanopyridines. The Cyano Group Can Be Used As An Ortho-Directing Group And Allows The Preparation Of 3-Halogeno-4-Cyanopyridines. Reactivity Of 2-And 3-Cyanopyridines Is Also Investigated And Seems To Give Similar Results. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetlet.2004.11.021

专利信息

专利号:WO-2014035829-A1
优先权日:2012-08-31
标题:Substituted 3-aminothieno[2,3-c]pyridine-2-carboxamide analogs as positive allosteric modulators
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; POSLUSNEY MICHAEL S; BRIDGES THOMAS M; Daniels john s
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 3-aminothieno[2,3-c]pyridine-2- carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.