CAS: 1963-21-9; (2S)-2-(2-Aminoacetamido)-3-Methylbutanoic Acid

该化合物是一种由氨酸甘油和valine构成的二极酸,其特点是相对简单的结构,其中甘油,最小的氨酸,通过浸泡物结合与L-valine相连.该化合物表面上一般为白色,外观为白色,在水中可溶解,这是许多peptides的共同特性.甘油-L-valine展示了的典型特性,包括参与各种生物化学反应和相互作用的能力.它可以在蛋白质合成中发挥作用,并可以参与代谢途径.此外,与其他一样,它可能展示具体的生物活动,尽管对其药理效应的详细研究可能有限.甘油-L-valine经常用于研究环境,特别是与浸泡物合成和氨酸新陈代谢有关的研究.其稳定性和溶解性使其在生物化学应用中成为有用的化合物,包括潜在的营养和治疗作用.

结构式图片

相似化合物

10521-49-0 86895-14-9 1307188-77-7

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合成工艺路线路线简述

  • 合成目标产物 Glycyl-L-Valine 主要起始原料 (S)-2-(2-((Tert-Butoxycarbonyl)Amino)Acetamido)-3-Methylbutanoic Acid
  • (文献来源)合成步骤主要原料 (S)-2-(2-((Tert-Butoxycarbonyl)Amino)Acetamido)-3-Methylbutanoic Acid
Glycine-L-Leucine Ethyl Ester Hydrochloride置于barium Dihydroxide体系中,化学反应生成甘氨酰-L-缬氨酸
参考文献:Losse; Schmidt,Chemische Berichte,1958,Vol. 91,P. 1068,1071
标题:Losse; Schmidt,Chemische Berichte,1958,Vol. 91,P. 1068,1071

海关参考信息

专利信息


专利号:US-2008125354-A1
优先权日:2005-11-21
标题 :Selective inhibition of matrix metalloproteinases
发明人:FIELDS GREGG B; HAMMER ROBERT
权利人:UNIV FLORIDA ATLANTIC; UNIV LOUISIANA STATE
摘要:Synthetic triple-helical peptides (THPs) are used for the design and synthesis of triple-helical transition state analog inhibitors. These inhibitors feature a phosphonate ester or phosphinic moiety in place of the scissle bond. These groups inhibit MMPs, and methods been developed for their convenient incorporation within a peptide sequence by solid-phase methods.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-2015328616-A1
优先权日:2014-05-13
标题:Surface mediated synthesis of polynucleotides, polypeptides and polysaccharides and related materials, methods and systems
发明人:GETHERS MATTHEW; GODDARD III WILLIAM A; WEISS PAUL S; RANDALL JOHN
权利人:CALIFORNIA INST OF TECHN
摘要:Surface mediated polymer synthesizing methods and related systems and materials are described where monomers are attached to monomer binding regions on a surface and subsequently form chemical bonds with adjacent monomers on the surface to form linear polymers selected from polynucleotide, polypeptides and polysaccharides.

专利号:EP-2588602-A1
优先权日:2010-07-01
标题:Variants of glucoamylase
发明人:DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN
权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC
摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

专利号:EP-3728618-A1
优先权日:2017-12-20
标题 :Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates

专利号:US-4755558-A
优先权日:1986-05-30
标题:Using internal marker
发明人:KALBAG SURESH M
权利人:BECKMAN INSTRUMENTS INC
摘要:A method is provided for quantitatively monitoring the deprotection and coupling reactions employed in the solid phase synthesis of peptides. The method entails synthesizing a peptide on a support matrix that has a first marker associated therewith. The amino acids employed in the peptide synthesis procedure have a second marker attached thereto, which can be the blocking group used for the amino acid. After the coupling or deprotection step a portion of the support matrix is processed to release first and second identifers from the first and second markers, respectively. The completeness of the coupling or deprotection step can be determined by comparing the relative amounts of the detected first and second identifiers. Novel compositions of matter are used in or produced during this method, including support matrixes having pyrolyzable markers attached thereto.
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主要参考文献

[参考文献]: Usha C, Et Al. Growth And Combined Experimental And Quantum Chemical Study Of Glycyl-L-Valine Crystal. Heliyon. 2019 May 4;5(5):E01574.

合成参考文献


摘要:G. F. Bryce, J. M. H. Pinkerton, L. K. Steinrauf and F. R. N. Gurd, J. Biol. Chem. 240, 3829 (1965).
参考文献:10.1007/s00726-008-0054-5
摘要:Doğan A, Ozel AD, Kiliç E. The protonation equilibria of selected glycine dipeptides in ethanol-water mixture: solvent composition effect. Amino Acids. 2009 Feb;36(2):373–9. doi: 10.1007/s00726-008-0054-5.
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