CAS: 26184-62-3; (S)-(+)-2-Pentanol

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CAS号139406-51-2 (R)-1,2-环氧基戊烷 | CAS号107-87-9 2-戊酮 | CAS号6032-29-7 仲戊醇 | CAS号142-62-1 正己酸 | CAS号143-07-7 月桂酸 | CAS号134176-72-0 (2S)-(2-tetrahy... | CAS号31087-44-2 (R)-(-)-2-戊醇 | CAS号109-66-0 正戊烷 | CAS号31087-44-2 (R)-(-)-2-戊醇 | CAS号20412-35-5 pentan-2-yl car... | CAS号1817-89-6 2-乙氧基戊烷 | CAS号107-87-9 2-戊酮 | CAS号67-63-0 异丙醇 | CAS号109-67-1 1-戊烯 | CAS号107-81-3 2-溴戊烷 | CAS号1809-10-5 3-溴戊烷 | CAS号637-97-8 2-碘戊烷 | CAS号1809-05-8 3-碘戊烷

2-戊醇 反应生成(S)-(+)-2-戊醇
参考文献:Dominant Role Of An Endothelium-Derived Hyperpolarizing Factor (Edhf)-Like Vasodilator In The Ciliary Vascular Bed Of The Bovine Isolated Perfused Eye
标题:Dominant Role Of An Endothelium-Derived Hyperpolarizing Factor (Edhf)-Like Vasodilator In The Ciliary Vascular Bed Of The Bovine Isolated Perfused Eye
摘要:以下是中文翻译: 评估了来自内皮的no,前列环素和内皮源性超极化因子(edhf)在介导乙酰胆碱和缓激肽引发的血管舒张反应中的作用,实验对象为牛孤立灌注眼的睫状血管床. 乙酰胆碱或缓激肽引起的血管舒张不受no合成酶抑制剂(l-Name,100 μm)或环氧化酶抑制剂(flurbiprofen,30 μm)的影响,但在给予高浓度kcl(30 Mm)或使用洗涤剂chaps(0.3%,2 Min)破坏内皮后,血管舒张几乎完全消失. 乙酰胆碱诱导的血管舒张不受atp敏感型k+通道抑制剂(glibenclamide,10 μm)的影响,但在给予非选择性k+通道抑制剂(tea,10 Mm)后显著减弱. 小导电钙敏感型k+通道(sk+ca)抑制剂(apamin,100 Nm)和大导电钙敏感型k+通道(bk+ca)抑制剂(iberiotoxin,50 Nm)对乙酰胆碱诱导的血管舒张无显著影响.相比之下,中/大导电钙敏感型k+通道抑制剂(charybdotoxin,50 Nm)强烈阻断了这些血管舒张反应,并揭示了血管收缩反应. Apamin(100 Nm)与sub-Threshold浓度的charybdotoxin(10 Nm)组合显著减弱乙酰胆碱诱导的血管舒张,而apamin(100 Nm)与iberiotoxin(50 Nm)组合无影响. 综上所述,高浓度kcl,Charybdotoxin或apamin与sub-Threshold浓度charybdotoxin的组合对血管舒张的强烈阻断,强烈表明牛孤立灌注眼中的血管舒张是由edhf介导的. British Journal Of Pharmacology (2001) 134,912-920; Doi:10.1038/sj.Bjp.0704332
Doi:10.1038/sj.Bjp.0704332

专利信息

专利号:US-6924385-B2
优先权日:2002-11-18
标 题:Method for synthesis of aliphatic isocyanates from aromatic isocyanates
发明人：LETTMANN CHRISTIAN; KOHLSTRUK STEPHAN; STOCHNIOL GUIDO; SPYROU EMMANOUIL
权利人:DEGUSSA
摘要:The invention relates to a method for synthesis of aliphatic isocyanates from aromatic isocyanates in substantially 3 stages. In particular, the invention relates to a method for synthesis of bis{4-isocyanatocyclohexyl}methane (H 12 MDI) from bis{4-isocyanatophenyl}methane (MDI). More especially, the invention relates to a method for synthesis of H 12 MDI with a trans-trans isomer content of <30%, preferably of <20%, particularly preferably of 5 to 15%.

专利号:US-11053227-B2
优先权日:2017-12-20
标 题:Process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction and novel synthesis intermediates
发明人：COLLI CORRADO; BERTOLINI GIORGIO; SADA MARA; GARIS FARIS; NISIC FILIPPO; BIANCHI ALDO; BIAGGI CINZIA; DI FABIO ROMANO; RONZONI SILVANO; BERTUOLO STEFANIA; PRANDI ADOLFO; MAIORANA STEFANO
权利人:OLON SPA
摘要:Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-8138346-B2
优先权日:2006-08-16
标题 :Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. n nThe substituents R, R 5 , R 6 , R 7 , R 8 and R 9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.

专利号:US-11046978-B2
优先权日:2016-03-16
标 题:Synthesis of isoprenoids and derivatives
发明人：GONZALEZ RAMON; CLOMBURG JAMES M; CHEONG SEOKJUNG
权利人:UNIV RICE WILLIAM M
摘要:This disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).