专利号:US-11040938-B2 优先权日:2016-07-27 标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts 发明人:MA BING; PAN SHUAI 权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH 摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.
专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:WO-2007007735-A1 优先权日:2005-07-12 标 题 :Synthesis of organic conductive polymerizable material onto metal oxide surface through light irradiation 发明人:TACHIBANA YASUHIRO 权利人:UNIV OSAKA; KANSAI TECH LICENSING ORG CO; TACHIBANA YASUHIRO 摘要:Disclosed is a composite material having a nanostructure containing metal oxide fine particles and an organic conductive polymerizable material. In this composite material, the metal oxide fine particles are joined with one another and the organic conductive polymerizable material is contained in the spaces between the fine particles. In this connection, the organic conductive polymerizable material is a copolymer which is composed of a polythiophene derivative, a thiophene or a derivative thereof and pyrrole, aniline, fluorene, furan or a derivative thereof. Also disclosed is a method for producing such a composite material. This composite material is useful for display elements such as electronic paper.
专利号:US-10557210-B2 优先权日:2014-02-24 标题 :Direct electrochemical synthesis of doped conductive polymers on metal alloys 发明人:KINLEN PATRICK JOHN; LAWLESS LAWRENCE MICHAEL 权利人:BOEING CO 摘要:This disclosure relates generally to the discovery of improved methods of reducing corrosion on metals and metal alloys without using hexavalent chromium reagents. More particularly, the disclosure relates to preparing corrosion resistant metals using doped conducting polymers such as polyaniline (PANI) on metal alloys such as aluminum alloys.
专利号:US-2018370905-A1 优先权日:2013-04-05 标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:US-2022281888-A1 优先权日:2019-09-25 标题:Bicyclic carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT; GORECZNY GREGORY 权利人:NIROGY THERAPEUTICS INC 摘要:The present invention generally relates to the field of transporter modulators, e.g., monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.