CAS: 329974-09-6; 4-Bromo-2,6-Diaminopyridine

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2,6-二溴-4-硝基吡啶氮氧化物置于ammonium Hydroxide,乙酰溴,铁粉,溶剂黄146体系中,用 水,溶剂黄146 作为反应溶剂,化学反应 10.0H,反应生成 4-溴-2,6-二氨基吡啶
参考文献:The Development Of A Practical And Reliable Large-Scale Synthesis Of 2,6-Diamino-4-Bromopyridine
标题:The Development Of A Practical And Reliable Large-Scale Synthesis Of 2,6-Diamino-4-Bromopyridine
摘要:A Novel,Safer,And Efficient Synthetic Route To 2,6-Diamino-4-Bromopyridine Has Been Developed. In Discovery Research A Five-Step Synthesis Afforded 2,6-Diamino-4-Bromopyridine In 56% Yield With A Double Curtius Rearrangement As A Key Transformation. Due To Potential Safety Concerns On Larger Scale An Alternative Synthetic Strategy Was Necessary. Starting From 2,4-Dibromopyridine-N-Oxide Two Complementary Procedures Have Been Developed To Access 2,6-Diamino-4-Bromopyridine. The Four-Step Procedure Yielded In 28% Overall,And The Five-Step Procedure,In 33% Overall 2,6-Diamino-4-Bromopyridine In A Safe And Straightforward Manner Using A Regioselective 2,6-Diamination Reaction As Key Step. Additionally,A General Route To Unsymmetrical Substituted Pyridine N-Oxide Derivatives Is Disclosed.
DOI:10.1021/op020085J