CAS: 3398-22-9; (2R,4S)-4-Hydroxypyrrolidine-2-Carboxylic Acid

相似化合物

142347-81-7 6912-67-0 51-35-4

上下游产品

CAS号77449-96-8 (2R,4R)-1-acety... | CAS号77449-95-7 N-Acetyl-allo-4... | CAS号114673-33-5 trans-1-(3,5-di... | CAS号618-28-0 trans-4-hydroxy... | CAS号481704-21-6 反式-4-羟基-L-脯氨酸甲酯盐酸盐 | CAS号634-97-9 吡咯-2-甲酸 | CAS号155153-78-9 (2R,4S)-N-ALPHA... | CAS号147266-92-0 N-B°C-反式-4-羟基-D-脯氨酸 | CAS号178962-09-9 (4S)-4-羟基-D-脯氨酸甲酯 | CAS号256487-77-1 N-B°C-4-羰基-L-脯氨酸甲酯 | CAS号1123307-53-8 2,5-Dibromo-N-[... | CAS号77450-03-4 (2R,4S)-4-羟基-2-...

专利信息

专利号:US-9433605-B2
优先权日:2006-03-23
标 题 :Method for promoting synthesis of tissue collagen
发明人：KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO
权利人:KYOWA HAKKO BIO CO LTD
摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-6117974-A
优先权日:1991-10-02
标题:Libraries of backbone-cyclized peptidomimetics
发明人：GILON CHAIM; HORNIK VERED
权利人:PEPTOR LTD; YISSUM RES DEV CO
摘要:Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N(((-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N(((-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity. Further embodiments of the invention are Interleukin-6 receptor derived peptides having ring structures involving backbone cyclization.

专利号:US-5166394-A
优先权日:1990-05-23
标题 :Coupling reagent for peptide synthesis
发明人：BREIPOHL GERHARD; KOENIG WOLFGANG
权利人:HOECHST AG
摘要:Novel compounds of the formula I ##STR1## in which X is an anion, and a process for the preparation thereof, are described. Compounds of the formula I are used as coupling reagents in peptide synthesis.

专利号:WO-2009140467-A1
优先权日:2008-05-15
标 题:Oxobenzindolizinoquinolines and uses thereof
发明人：CUSHMAN MARK S; CINELLI MARIS A; MORRELL ANDREW E; POMMIER YVES G
权利人:PURDUE RESEARCH FOUNDATION; CUSHMAN MARK S; US GOV HEALTH & HUMAN SERV; CINELLI MARIS A; MORRELL ANDREW E; POMMIER YVES G
摘要:The synthesis of aromathecins, substituted 12 H -5,l la-diazadibenzo[ b,h ]fluoren- 11 -ones is described. Use of these cytotoxic compounds and pharmaceutical compositions containing them for the treatment of cancer is described. Two novel processes for the synthesis of this system and a series of 14-substituted aromathecins as novel cytotoxic, topoisomerase I poisons are described.

专利号:TW-I224010-B
优先权日:1999-03-02
标 题 :Promoter of proliferation of epidermal cells, promoter of collagen synthesis of fibroblasts and heightening agent of water-preservative function of epidermis