CAS: 491-37-2; 4-Chromanone

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3-苯氧基丙腈置于盐酸,Alpha-(1-氨基乙基)-苯甲醇体系中,用 水 作为反应溶剂,化学反应 7.0H,反应生成 2,3-二氢苯并吡喃-4-酮
参考文献:双位苯并吡喃吗啉类似物作为选择性多巴胺 D3 受体配体作为抗毒瘾治疗剂的设计,合成和初步生物活性评估
标题:双位苯并吡喃吗啉类似物作为选择性多巴胺 D3 受体配体作为抗毒瘾治疗剂的设计,合成和初步生物活性评估
摘要:三个系列的双位苯并吡喃吗啉类似物被设计,合成和评估为多巴胺 D3 受体的一类新型选择性配体.使用放射性配体结合测定法测定目标化合物的结合亲和力.大多数化合物对 D3 受体表现出相当大的结合亲和力和选择性.此外,还筛选了这些化合物在动物行为模型中缓解阿片类药物成瘾戒断症状的能力.结果表明,化合物20H对d3R表现出纳摩尔亲和力,并在纳洛酮诱导的吗啡依赖小鼠戒断症状动物模型中表现出抗毒瘾功效.
DOI:10.1016/j.Bmcl.2021.128269

专利信息

专利号:US-8569560-B2
优先权日:2006-10-13
标题 :Synthesis of terminal alkenes from internal alkenes via olefin metathesis
发明人：SCHRODI YANN; PEDERSON RICHARD L; KAIDO HIROKI; TUPY MICHAEL J
权利人:ELEVANCE RENEWABLE SCIENCES
摘要:This disclosure relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by an olefin metathesis catalyst. According to one aspect, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting, in the presence of a ruthenium alkylidene metathesis catalyst, an olefinic substrate comprised of at least one internal olefin with a cross metathesis partner comprised of an alpha olefinic reactant, under reaction conditions effective to allow cross-metathesis to occur, wherein the reaction conditions include a reaction temperature of at least 35° C. The methods, compositions, reactions and reaction systems herein disclosed have utility in the fields of catalysis, organic synthesis, and industrial chemistry.

专利号:US-2006167025-A1
优先权日:2004-12-22
标 题:Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
发明人：BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
权利人:BERGER MARKUS; SCHMEES NORBERT; SCHAECKE HEIKE; BAURLE STEFAN; REHWINKEL HARTMUT; MENGEL ANNE; KROLIKIEWICZ KONRAD; GROSSBACH DANJA; VOIGTLAENDER DAVID
摘要:The invention relates to tricyclic amino alcohols of general formula (I) n nmethod for synthesis of same and use of same as anti-inflammatory agents.

专利号:US-10487099-B2
优先权日:2017-06-30
标 题:Synthesis of hypervalent iodine reagents with dioxygen
发明人：POWERS DAVID CHARLES; MAITY ASIM; HYUN SUNG-MIN
权利人:TEXAS A & M UNIV SYS
摘要:Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.

专利号:US-6946533-B2
优先权日:2002-08-01
标 题 :Synthesis of macrocyclic polymers by ring insertion polymerization of cyclic olefin monomers
发明人：GRUBBS ROBERT; BIELAWSKI CHRIS; BENITEZ DIEGO
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing cyclic polymers using transition metal alkylidene complexes as reaction catalysts is provided, wherein the complexes contain a cyclic group. Polymerization is carried out on the catalyst, using cyclic olefin monomers that undergo ring insertion polymerization, and no linear intermediates are generated. Following completion of polymerization, the cyclic polymer detaches from the complex via an intramolecular chain transfer reaction and the catalytic complex is regenerated. The invention also provides novel transition metal alkylidene complexes useful as catalysts in the aforementioned process, as well as novel cyclic hydrocarbons.

专利号:US-2004044225-A1
优先权日:2001-06-01
标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives
发明人：KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK
摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.

专利号:US-11794179-B2
优先权日:2016-08-24
标 题 :Synthesis and characterization of metathesis catalysts
发明人：JOHNS ADAM M
权利人:UMICORE AG & CO KG
摘要:This invention relates generally to olefin metathesis catalysts, to the preparation of such compounds, compositions comprising such compounds, methods of using such compounds, and the use of such compounds in the metathesis of olefins and in the synthesis of related olefin metathesis catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and in industrial applications such as oil and gas, fine chemicals and pharmaceuticals.