6,7-二羟基香豆素-7-苄醚置于甲醇,Sodium Hydroxide,Pd-Baso4,Alkaline Solution,丙酮体系中,化学反应生成 秦皮甲素 参考文献:Amiard; Nomine,Bulletin De La Societe Chimique De France,1948,P. 476,478 标题:Amiard; Nomine,Bulletin De La Societe Chimique De France,1948,P. 476,478
专利号:US-6150130-A 优先权日:1993-12-27 标题 :DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls 发明人:MISAWA NORIHIKO; KONDO KEIJI; KAJIWARA SUSUMU; YOKOYAMA AKIHIRO 权利人:KIRIN BREWERY; MARINE BIOTECH INST CO LTD 摘要:Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering: A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a beta -ionone ring into a keto group. A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy- beta -ionone ring into a keto group. A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto- beta -ionone ring. It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.
专利号:US-7255989-B1 优先权日:1999-11-29 标 题:Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds 发明人:JEANNIN PASCALE; PERNODET JEAN-LUC; GUERINEAU MICHEL; SIMONET PASCAL; COURTOIS SOPHIE; CAPPELLANO CAMELA; FRANCOU FRANCOIS; RAYNAL ALAIN; BALL MARIA; SEZONOV GUENNADI; TUPHILE KARINE; FROSTEGARD ASA 权利人:AVENTIS PHARMA SA 摘要:The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.
专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2006115880-A1 优先权日:2002-12-03 标 题 :Enzymatic production of acyl flavonoid derivatives 发明人:GHOUL MOHAMED; ENGASSER JEAN-MARC; MOUSSOU PHILIPPE; PAULY GILLES; ARDHAOUI MELIKA; FALCIMAIGNE AUDE 权利人:COGNIS FRANCE SA 摘要:Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.
专利号:US-5095819-A 优先权日:1985-08-21 标 题:Method for the printed reproduction of continuous-tone polychrome originals 发明人:AGOSTINI DARIO; FINO ALBERTO; MASCARELLO FRANCO; SCIARRETTA BENITO 权利人:ILTE IND LIBRARIA TIPOGRAFICA 摘要:Continuous-tone polychrome subjects (O) are reproduced by ink printing on a substrate. The reproduction is achieved by the synthesis of three chromatic components, one of which corresponds to the color of the substrate and the other two of which correspond to the colored inks used for the printing. In one variant of the method, one of the colored inks is replaced by a black ink, printed with a plate made from the achromatic component of the subject.
参考文献:10.1007/s00248-011-9904-x 摘要:Lo Giudice A, Caruso C, Mangano S, Bruni V, De Domenico M, Michaud L. Marine bacterioplankton diversity and community composition in an antarctic coastal environment. Microb Ecol. 2012 Jan;63(1):210–23. doi: 10.1007/s00248-011-9904-x. 参考文献:10.1007/s00203-011-0730-9 摘要:Chen WM, Sheu FS, Sheu SY. Aquimarina salinaria sp. nov., a novel algicidal bacterium isolated from a saltpan. Arch Microbiol. 2012 Feb;194(2):103–12. doi: 10.1007/s00203-011-0730-9. 参考文献:10.1007/s00216-011-5227-5 摘要:Kuehl B, Marten S, Bischoff Y, Brenner-Weiß G, Obst U. MALDI-ToF mass spectrometry–multivariate data analysis as a tool for classification of reactivation and non-culturable states of bacteria. Analytical and Bioanalytical Chemistry. 2011 Jul 17;401(5):1593. doi: 10.1007/s00216-011-5227-5. 参考文献:10.1007/s10295-011-1015-7 摘要:Wang J, Zhang W, Zhong Z, Wei A, Bao Q, Zhang Y, Sun T, Postnikoff A, Meng H, Zhang H. Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk. Journal of Industrial Microbiology & Biotechnology. 2011 Jul 22;39(1):191–206. doi: 10.1007/s10295-011-1015-7.