CAS: 6933-10-4; 4-Bromo-3-Methylaniline

上下游产品

CAS号7149-70-4 2-溴-5-硝甲苯 | CAS号615-59-8 2,5-二溴甲苯 | CAS号1097885-39-6 4-azido-1-bromo... | CAS号108-44-1 3-甲基苯胺 | CAS号537-92-8 N-乙酰基-3-甲苯胺 | CAS号620-25-7 META-TOLYLHYDRO... | CAS号582-77-4 Benzamide, N-m-tolyl | CAS号7732-18-5 水 | CAS号7726-95-6 溴素 | CAS号112183-11-6 N-(4-bromo-3-me... | CAS号106976-23-2 5-溴-6-甲基靛红 | CAS号106976-22-1 4-methyl-5-brom... | CAS号41963-20-6 4-溴-3-甲基苯甲腈 | CAS号14395-52-9 4-bromo-3-methy... | CAS号452-63-1 2-溴-5-氟甲苯 | CAS号188592-61-2 N-(4-bromo-3-me... | CAS号197450-40-1 4-[2-methyl-4-(... | CAS号28170-76-5 3-(4-bromo-3-me... | CAS号289617-98-7 1-Bromo-2-(brom...

3-甲基苯胺置于氢溴酸,二甲基亚砜体系中,化学反应 2.0H,以79%的收率获得产物4-溴-3-甲基苯胺
参考文献:在温和条件下用 Dmso/hbr 选择性溴化吡咯衍生物,咔唑和芳香胺
标题:在温和条件下用 Dmso/hbr 选择性溴化吡咯衍生物,咔唑和芳香胺
摘要:使用 Dmso/hbr 系统溴化吡咯衍生物,咔唑和芳香胺可提供相应溴化合物的高产率.苯胺溴化中使用的温度控制有助于促进单溴化或二溴化产品的选择性形成.操作简单,毒性低,选择性高,使其成为一种很有前途的芳香族化合物溴化新工艺.
DOI:10.3184/174751914X14114780483352

专利信息

专利号:US-8853410-B2
优先权日:2009-04-30
标 题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6417195-B1
优先权日:1999-02-22
标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：LEBL MICHAL
权利人:LION BIOSCIENCE AG
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

专利号:US-5874443-A
优先权日:1995-10-19
标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
发明人：KIELY JOHN S; GRIFFITH MICHAEL C
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.