CAS: 704-15-4; H-Gly-Pro-Oh

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CAS号147-85-3 脯氨酸 | CAS号1160-54-9 N-苄氧羰基甘氨酰-L-脯氨酸 | CAS号212651-48-4 (S)-1-(2-((((9H... | CAS号56-40-6 甘氨酸 | CAS号23500-10-9 1-(2-氯乙酰基)脯氨酸 | CAS号60189-43-7 glycylproline 4... | CAS号2646-61-9 Z-Gly-Pro-Leu-G... | CAS号3705-27-9 环(甘氨酸-L-脯氨酸)二肽 | CAS号33256-35-8 H-Pro-Gly-OMe | CAS号56-40-6 甘氨酸 | CAS号147-85-3 脯氨酸 | CAS号14296-92-5 B°C-甘氨酸-L-脯氨酸

Z-甘氨酸-脯氨酸置于甲醇,钯,溶剂黄146体系中,化学反应生成 甘油-L-脯氨酸
参考文献:702.多肽.第四部分 甘氨酸和脯氨酸某些肽的酯的自缩合
标题:702.多肽.第四部分 甘氨酸和脯氨酸某些肽的酯的自缩合
摘要:
DOI:10.1039/jr9560003642

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-5405949-A
优先权日:1993-03-29
标题 :Process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid
发明人：UNGARELLI FABRIZIO; PIANI SILVANO
权利人:ALFA WASSERMANN SPA
摘要:A process for the synthesis of glycosaminoglycans with heparin or heparan structure modified in position 2 of the α-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substituted with a nucleophilic group, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

专利号:US-5410039-A
优先权日:1993-03-29
标题 :Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3
发明人：UNGARELLI FABRIZIO; PIANI SILVANO
权利人:ALFA WASSERMANN SPA
摘要:A process for the synthesis of glycosaminoglycans in which one of the α-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into α-L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

专利号:WO-2023227913-A1
优先权日:2022-05-27
标 题:Creating nucleic acids for in-vitro protein synthesis
发明人：CHEN MICHAEL CHUN HAO; MCINROY GORDON ROSS; OST TOBIAS WILLIAM BARR
权利人:NUCLERA LTD
摘要:Provided herein are methods, and compositions for the synthesis of genes and proteins. The methods are applicable to synthesis of nucleic acids and proteins on a microfluidic device.

专利号:US-2004033532-A1
优先权日:2002-08-08
标题 :Use of three-dimensional crystal structure coordinates to design and synthesize domain-selective inhibitors for angiotensin-converting enzyme (ACE)
发明人：EHLERS MARIO R W; HOLMQUIST BARTON
摘要:It has now been discovered that the use of the three-dimensional crystal structure coordinates of angiotensin-converting enzyme (ACE) will enable the design and synthesis, by means of computational chemistry and structure-guided drug design, of inhibitors of ACE that are highly selective and specific for either the N domain or the C domain of the enzyme, for the treatment of diverse diseases. The invention also relates to methods and processes for the structure-guided design and synthesis of dual N- and C-domain ACE inhibitors, and inhibitors that operate by competitive, non-competitive, uncompetitive, and irreversible mechanisms.

专利号:US-5219741-A
优先权日:1989-09-06
标题:Method of making L-proline using an N-acyl-L-protine acylase
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.