CAS: 84476-99-3; 2,5-Difluoropyridine

• 英文名称2,5-Difluoropyridine
• 中文名称2,5-二氟吡啶
• IUPAC名称2,5-difluoropyridine
• 其它别名2,5-二氟吡啶((2周; 25二氟吡啶; Pyridine, 2,5-Difluoro-; 2,5-Difluoropyridine
• CAS编号84476-99-3
• MFCD编号:MFCD04114191
• EINECS号:674-957-3
• 分子式:C5H3F2N
• 分子量:115.08
• 产品CID: 1833204
• 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

• 相似结构搜索
• 产品信息参考
• InChIKey: XFAMUOYNXFXQTC-UHFFFAOYSA-N
• InChI=1S/C5H3F2N/c6-4-1-2-5(7)8-3-4/h1-3H…
• 计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点-33 °C
• 沸点113.1°C at 760 mmHg
• 闪点24°C
• 密度1.3±0.1 g/cm3
• pKa:-2.85±0.10(预测)
• PSA:12.89
• LogP:1.3598
• 折射率1.447
• 蒸汽压24.9±0.2 mmHg at 25°C
• 外观形态无色至淡黄色透明液体
• 储存条件惰性气氛,2-8°C
• 产品应用该化合物用作中间药,例如,合成乙基8-氯-1-环丙酰-7-氟-九-甲基-四甲基-氧-4-H-丙基苯[2,3-B]-丙烯三-碳酸酯,这是生产一种抗菌剂的关键中间剂.

MSDS等安全信息

• GHS象形图
• GHS符号GHS02 & GHS07;
  注释: Flame & Exclamation mark
• 危险类别易燃液体 类别3
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H226 |易燃液体和蒸气.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P210-P302+P352
• 危险等级3
• UN编号1993.0
• 危险品标志T,F,Xi,Xn
• 包装等级Ⅲ
• 安全声明16-26-36/37/39-37
• 危险类别码10-36/37/38-22
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2,5-Difluoropyridine 主要起始原料 2,3,5,6-Tetrafluoropyridine
• 851179-00-5 = 84476-99-3
  反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: Acetic Acid,Water; 2 H,25 °C
  标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
  作者:Bobbio,Carla; Et Al
  参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]
  
  = 84476-99-3 [标题:Reaction Conditions
  标题:Fluorinations With Potassium Tetrafluorocobaltate(Iii). Part Vii. Further Investigations On The Fluorination Of Pyridine
  作者:Coe,Paul L.; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:1982 卷标:21(2) 页码:171-89]
  
  = 84476-99-3 [标题:Reaction Conditions
  标题:Fluorinations With Complex Metal Fluorides. Part 6. Fluorination Of Pyridine And Related Compounds With Cesium Tetrafluorocobaltate(Iii)
  作者:Plevey,Raymond G.; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:1982 卷标:21(2) 页码:159-69]
  
  2879-42-7 = 84476-99-3
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 20 H,-5 °C2.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,Reflux
  标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
  作者:Bobbio,Carla; Et Al
  参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]
  
  1735-84-8 = 84476-99-3
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 1.25 H,-10 °C -> 0 °C2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 20 H,-5 °C3.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,Reflux
  标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
  作者:Bobbio,Carla; Et Al
  参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]
  
  700-16-3 = 84476-99-3 + 71902-33-5
  反应条件:1.1 Reagents: Triethylsilane Catalysts: (Oc-6-43)-[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylide... Solvents: Tetrahydrofuran; 28 H,343 K2.1 Reagents: Triethylsilane Catalysts: (Oc-6-43)-[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylide... Solvents: Tetrahydrofuran; 3 D,343 K
  标题:Mechanistic Study Of Ru-Nhc-Catalyzed Hydrodefluorination Of Fluoropyridines: The Influence Of The Nhc On The Regioselectivity Of C-F Activation And Chemoselectivity Of C-F Versus C-H Bond Cleavage
  作者:Mckay,David; Et Al
  参考文献:Acs Catalysis 日期:2015 卷标:5(2) 页码:776-787]
  
  2875-18-5 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  6485-79-6 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene-D8; 2 H,Rt2.1 Solvents: Toluene; 3 D,Rt3.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene-D8; 8 H,Rt -> 50 °C2.1 Solvents: Toluene; 3 D,Rt3.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene-D8; 8 H,Rt -> 50 °C2.1 Solvents: Toluene; 3 D,Rt3.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  617-86-7 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene-D8; -30 °C; 20 H,-15 °C2.1 Solvents: Toluene-D8; 2 H,Rt3.1 Solvents: Toluene; 3 D,Rt4.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  851179-04-9 = 84476-99-3
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 45 Min,Reflux
  标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
  作者:Bobbio,Carla; Et Al
  参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]
  
  = 84476-99-3 [标题:Reaction Conditions
  标题:Fluorinations With Complex Metal Fluorides. Part 6. Fluorination Of Pyridine And Related Compounds With Cesium Tetrafluorocobaltate(Iii)
  作者:Plevey,Raymond G.; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:1982 卷标:21(2) 页码:159-69]
  
  76469-41-5 = 84476-99-3 + 71902-33-5
  反应条件:1.1 Reagents: Triethylsilane Catalysts: (Oc-6-43)-[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylide... Solvents: Tetrahydrofuran; 3 D,343 K
  标题:Mechanistic Study Of Ru-Nhc-Catalyzed Hydrodefluorination Of Fluoropyridines: The Influence Of The Nhc On The Regioselectivity Of C-F Activation And Chemoselectivity Of C-F Versus C-H Bond Cleavage
  作者:Mckay,David; Et Al
  参考文献:Acs Catalysis 日期:2015 卷标:5(2) 页码:776-787]
  
  700-16-3 + 99476-19-4 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene; 3 D,Rt2.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  700-16-3 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C2.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142]
  
  6485-79-6 = 84476-99-3 + 76469-41-5 + 71902-33-5 + 3512-18-3 + 372-47-4
  反应条件:1.1 Solvents: Toluene-D8; -30 °C; 20 H,-15 °C2.1 Solvents: Toluene-D8; 8 H,Rt -> 50 °C3.1 Solvents: Toluene; 3 D,Rt4.1 Reagents: Triethylsilane Catalysts: Di-μ-Hydrobis[1,1′-(1,3-Propanediyl)Bis[1,1-Bis(1-Methylethyl)Phosphine-Kp]]Dirh... Solvents: Benzene-D6; 48 H,Rt -> 50 °C
  标题:Catalytic Hydrodefluorination Of Fluoroaromatics With Silanes As Hydrogen Source At A Binuclear Rhodium Complex: Characterization Of Key Intermediates
  作者:Zamostna,Lada; Et Al
  参考文献:Journal Of Fluorine Chemistry 日期:2013 卷标:155 页码:132-142

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管