CAS: 947-91-1; 2,2-Diphenylacetaldehyde

该化合物是一种高纯度的有机化合物,主要用作合成药品,香料和精美化学品的中间体.其芳香结构由两个联苯组组成,附于一个丙烯菊酯协会,使它成为各种化学反应,包括凝聚和减少的多功能构件.产品的纯度(>80%)确保了在需要精确再活性的应用中始终如一的性能.它因其在生产手性化合物和作为制造调味剂的先质方面的作用而特别受到重视.建议在空气条件下妥善储存以保持稳定和防止氧化.适合实验室和工业规模的工艺.

英文名称2,2-Diphenylacetaldehyde
中文名称2,2-二苯基乙醛
IUPAC名称2,2-diphenylacetaldehyde
其它别名二苯基乙醛; 联苯乙醛; Nsc 21645; Diphenyl Acetaldehyde; Diphenylacetaldehyde
CAS编号947-91-1
MFCD编号:MFCD00006972
EINECS号:213-433-7
FDA UNII编号:GMF2B8R7DD
分子式:C14H12O
分子量:196.24
产品CID: 2000284
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: HLLGFGBLKOIZOM-UHFFFAOYSA-N
InChI=1S/C14H12O/c15-11-14(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-11,14H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数3.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明23-24/25
危险类别码R36/37/38:对眼睛,呼吸道和皮肤有刺激作用.
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

1,1-Diphenylethylene Perbenzoic acid chloroform 1,1-diphenyloxirane1,1-Diphenyl-2-morpholino-aethan 1,1-diphenyl-2-propanol 3-hydroxy-2,2-diphenyl-propionaldehyde Benzoesaeure-2,2-diphenylethenylester

合成工艺路线路线简述

35479-44-8 = 947-91-1
反应条件:1.1 Reagents: Chlorotrimethylsilane,Zinc Solvents: Acetonitrile1.2 Reagents: Styrene
标题:Zinc-Promoted Reactions. Part 11. Ionic Reactions And Single Electron Transfers In The Zn/tmsci Reduction Of Benzaldehyde
作者:Di Vona,Maria Luisa; Rosnati,Vittorio
参考文献:Main Group Metal Chemistry 日期:1999 卷标:22(2) 页码:89-94]

1439-07-2 = 947-91-1
反应条件:1.1 Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Erbium(3+) Salt (3:1) Solvents: Dichloromethane; 45 Min,Rt
标题:Erbium(Iii) Triflate: A Valuable Catalyst For The Rearrangement Of Epoxides To Aldehydes And Ketones
作者:Procopio,Antonio; Dalpozzo,Renato; De Nino,Antonio; Nardi,Monica; Sindona,Giovanni; Et Al
参考文献:Synlett 日期:2004 卷标:(14) 页码:2633-2635]

882-59-7 = 947-91-1
反应条件:1.1 Catalysts: Iridium(1+),[(1,2,5,6-η)-1,5-Cyclooctadiene]Hydro[(8-Quinolinyl-Kn)Methyl-Kc](T... Solvents: Tetrahydrofuran; 23 °C; 24 H,100 °C
标题:An Air-Stable Cationic Iridium Hydride As A Highly Active And General Catalyst For The Isomerization Of Terminal Epoxides
作者:Humbert,Nicolas; Vyas,Devendra J.; Besnard,Celine; Mazet,Clement
参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(73) 页码:10592-10595]

2425-29-8 = 947-91-1
反应条件:1.1 Reagents: Trifluoroacetic Acid,Diethylzinc Solvents: Dichloromethane; 0 °C; 30 Min,0 °C1.2 0 °C; 10 Min,0 °C
标题:Cf3Co2Znet-Mediated Highly Regioselective Rearrangement Of Bromohydrins To Aldehydes
作者:Wang,Zhihui; Li,Meiyi; Zhang,Wenqin; Jia,Jiangnan; Wang,Fei; Et Al
参考文献:Tetrahedron Letters 日期:2011 卷标:52(45) 页码:5968-5971]

25017-18-9 = 947-91-1
反应条件:1.1 Reagents: (T-4)-Bromohydro[1,1′-Thiobis[methane]](1,1,2-Trimethylpropyl)Boron Solvents: Dichloromethane
标题:Facile Reduction Of Saturated And Unsaturated Carboxylic Acids And Their Salts To Aldehydes By Thexylbromoborane-Dimethyl Sulfide
作者:Cha,Jin Soon; Kim,Jin Euog; Lee,Kwang Woo
参考文献:Journal Of Organic Chemistry 日期:1987 卷标:52(22) 页码:5030-2]

17619-97-5 = 947-91-1
反应条件:1.1 Catalysts: Trifluoroacetic Acid Solvents: 1,4-Dioxane; 5 Min,Rt
标题:Triflic-Acid-Catalyzed Tandem Epoxide Rearrangement And Annulation With Alkynes: An Efficient Approach For Regioselective Synthesis Of Naphthalenes
作者:Rao,Chinthu Joginarayana; Sudheer,Mokhamatam; Battula,Venkateswara Rao
参考文献:Chemistryselect 日期:2022 卷标:7(9)]

1689-71-0 = 947-91-1
反应条件:1.1 Catalysts: Pentacyclo[19.3.1.13,7.19,13.115,19]Octacosa-1(25),3,5,7(28),9,11,13(27),15,17,1... Solvents: Chloroform-D,Water; 18 H,60 °C
标题:Efficient Epoxide Isomerization Within A Self-Assembled Hexameric Organic Capsule
作者:Caneva,Thomas; Sperni,Laura; Strukul,Giorgio; Scarso,Alessandro
参考文献:Rsc Advances 日期:2016 卷标:6(87) 页码:83505-83509]

1689-71-0 = 947-91-1
反应条件:1.1 Catalysts: Iron(1+),Dicarbonyl(η5-2,4-Cyclopentadien-1-Yl)(Tetrahydrofuran)-,Tetrafluorob... Solvents: Dichloromethane
标题:Iron Lewis Acid Catalyzed Reactions Of Phenyldiazomethane With Aromatic Aldehydes
作者:Mahmood,Syed J.; Saha,Anjan K.; Hossain,M. Mahmun
参考文献:Tetrahedron 日期:1998 卷标:54 页码:349-358]

25017-18-9 = 947-91-1
反应条件:1.1 Reagents: 9-Borabicyclo[3.3.1]Nonane Solvents: Tetrahydrofuran
标题:Exceptionally Facile Reduction Of Carboxylic Acid Salts To Aldehydes By 9-Borabicyclo[3.3.1]Nonane
作者:Cha,Jin Soon; Oh,Se Yeon; Lee,Kwang Woo; Yoon,Mal Sook; Lee,Jae Cheol; Et Al
参考文献:Heterocycles 日期:1988 卷标:27(7) 页码:1595-8]

1439-07-2 = 947-91-1
反应条件:1.1 Reagents: Trifluoroacetic Acid,3H-Oxazirino[3,2-A]Isoquinolinium,4,8B-Dihydro-2-Methyl-,Tetrafluoroborate(1-)...
标题:Oxygen Transfer To Ethylenic Double Bonds From An Oxaziridinium Salt
作者:Hanquet,G.; Lusinchi,X.; Milliet,P.
参考文献:Tetrahedron Letters 日期:1988 卷标:29(32) 页码:3941-4]

1439-07-2 = 947-91-1
反应条件:1.1 Catalysts: Methylium,Triphenyl-,Tetrafluoroborate(1-) (1:1) Solvents: Dichloromethane; 5 Min,Rt
标题:Carbocations As Lewis Acid Catalysts: Reactivity And Scope
作者:Bah,Juho; Naidu,Veluru Ramesh; Teske,Johannes; Franzen,Johan
参考文献:Advanced Synthesis & Catalysis 日期:2015 卷标:357(1) 页码:148-158]

4217-62-3 = 947-91-1
反应条件:1.1 Reagents: Sulfuric Acid
标题:Synthesis Of Aldehydes And Ketones From Asymm.-Disubstituted Ethylene Glycols And Their Ethers
作者:Stoermer,R.
参考文献:Berichte Der Deutschen Chemischen Gesellschaft 日期:1906 卷标:39 页码:2288-2306]

25017-18-9 = 947-91-1
反应条件:1.1 Reagents: Borane Solvents: Tetrahydrofuran1.2 Reagents: Dimethyl Sulfate1.3 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane
标题:Transformation Of Carboxylic Acid Salts To Aldehydes By Stepwise Reduction With Borane And Oxidation With Pyridinium Chlorochromate
作者:Cha,Jin Soon; Park,Jae Hyung; Moon,Suk Joung
参考文献:Bulletin Of The Korean Chemical Society 日期:2001 卷标:22(10) 页码:1089-1092]

1439-07-2 = 947-91-1
反应条件:1.1 Catalysts: Aluminum,Methyl[[2,2′-Sulfonylbis[6-Bromo-4-(1,1-Dimethylethyl)Phenolato-Ko]](2... Solvents: Dichloromethane
标题:Synthesis And Properties Of New Types Of Sulfoxide- Or Sulfone-Bridged Lewis Acids
作者:Ohba,Yoshihiro; Ito,Kazuaki; Nagasawa,Tomomi; Sakurai,Shinya
参考文献:Journal Of Heterocyclic Chemistry 日期:2000 卷标:37(5) 页码:1071-1076]

1439-07-2 = 947-91-1
反应条件:1.1 Catalysts: Copper(Ii) Triflate Solvents: Dichloromethane; 40 Min,Rt
标题:Copper(Ii)-Catalyzed Formation Of 1,3-Dioxolanes From Oxiranes
作者:Lee,Seung-Han; Lee,Jae-Chul; Li,Ming-Xing; Kim,Nam-Sun
参考文献:Bulletin Of The Korean Chemical Society 日期:2005 卷标:26(2) 页码:221-222]

1439-07-2 = 947-91-1
反应条件:1.1 Catalysts: Gold Trichloride,Silver Hexafluoroantimonate Solvents: 1,4-Dioxane; 5 Min,Rt
标题:Aucl3/agsbf6-Catalyzed Rapid Epoxide To Carbonyl Rearrangement
作者:Gudla,Vanajakshi; Balamurugan,Rengarajan
参考文献:Tetrahedron Letters 日期:2012 卷标:53(39) 页码:5243-5247]

1716-11-6 = 947-91-1
反应条件:1.1 Reagents: Dimethyl Sulfate,Borane Solvents: Tetrahydrofuran1.2 Reagents: Pyridinium Chlorochromate Solvents: Dichloromethane
标题:Exceptionally Facile Conversion Of Carboxylic Acid Salts To Aldehydes By Reductive Oxidation With Borane And Pyridinium Chlorochromate
作者:Cha,Jin Soon; Park,Jae Hyung; Lee,Dae Yon
参考文献:Bulletin Of The Korean Chemical Society 日期:2001 卷标:22(3) 页码:325-326]

492-70-6 = 947-91-1 [标题:Reaction Conditions
标题:Application Of Microwave Heating Techniques For Dry Organic Reactions
作者:Ben Alloum,Abdelkrim; Labiad,Bouchta; Villemin,Didier
参考文献:Journal Of The Chemical Society 日期:1989 卷标:(7) 页码:386-7]

17619-97-5 = 947-91-1
反应条件:1.1 Catalysts: Aluminum,(5′-Bromo[1,1′:3′,1′′-Terphenyl]-2′-Olato)Dimethyl- Solvents: Dichloromethane
标题:A Convenient Procedure For Rearrangement Of Epoxides By Use Of Dimethylaluminum Catalysts
作者:Nagahara,Shigeru; Maruoka,Keiji; Yamamoto,Hisashi
参考文献:Nippon Kagaku Kaishi 日期:1993 卷标:(7) 页码:893-6]

117-34-0 = 947-91-1
反应条件:1.1 Reagents: 9-Borabicyclo[3.3.1]Nonane Solvents: Tetrahydrofuran1.2 Reagents: Borate(1-),1,5-Cyclooctanediyldihydro-,Lithium (1:1),(T-4)- Solvents: Tetrahydrofuran1.3 Reagents: Water Solvents: Tetrahydrofuran
标题:One-Pot Conversion Of Carboxylic Acids To Aldehydes Through Treatment Of Acyloxy-9-Borabicyclo[3.3.1]Nonanes With Lithium 9-Boratabicyclo[3.3.1]Nonane
作者:Cha,Jin Soon; Kim,Jin Euog; Oh,Se Yeon; Kim,Jong Dae
参考文献:Tetrahedron Letters 日期:1987 卷标:28(39) 页码:4575-8

反式-1,2-二苯乙烯置于叔丁基过氧化氢,水体系中,用水作为反应溶剂,化学反应 24.0H,反应生成联苯乙醛
参考文献:一种双功能铁纳米复合催化剂,可将烯烃高效氧化为酮和1,2-二酮
标题:一种双功能铁纳米复合催化剂,可将烯烃高效氧化为酮和1,2-二酮
摘要:我们在此报告了一种双功能铁纳米复合催化剂的制备,其中两个fe-n X催化活性位点磷酸铁和铁的氧化位和路易斯酸位同时被整合到一个分层的n,P-双掺杂多孔碳中.作为一种双功能催化剂,它具有非常好的催化作用,可在较温和的反应条件下使用tbhp作为氧化剂,将烯烃直接氧化裂解为酮或将其氧化为1,2-二酮,具有广泛的底物范围,并具有较高的官能团耐受性.此外,可以很容易地将其回收以进行后续回收,而不会造成明显的活性损失.机理研究表明,烯烃的直接氧化是通过形成环氧化物作为中间体,然后进行酸催化的meinwald重排而产生的,该酮的碳原子短了一个或亲核开环,从而以级联方式反应生成1,2-二酮.
DOI:10.1021/acscatal.9B05197

海关参考信息

2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-2014275582-A1
优先权日:2013-03-14
标题 :Chiral 2-arylpropyl-2-sulfinamide and chiral n-2-arylpropyl-2-sulfinylimines and synthesis thereof
发明人：LI GUIGEN
权利人:LI GUIGEN; UNIV TEXAS TECH; NANJING UNIVERSITY INST OF CHEMISTRY AND BIOMEDICAL SCIENCES
摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

专利号:US-2005014954-A1
优先权日:2001-11-22
标题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

专利号:US-8026383-B2
优先权日:2001-07-06
标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
权利人:BASF SE
摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or â€”N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.

专利号:WO-2012164484-A1
优先权日:2011-05-30
标题:Adenosine or deoxyadenosine derivatives modified at position 8 and a method of synthesis thereof
发明人：CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
权利人:CONSIGLIO NAZIONALE RICERCHE; CAPOBIANCO MASSIMO LUIGI; NAVACCHIA MARIA LUISA
摘要:New derivatives of adenosine and deoxyadenosine modified at position 8 of the purine ring, of general formula (I) are described, which are suitable to be conjugated with functional molecules such as chromophores, fluorophores and intercalating residues, and suitable to be incorporated within synthetic oligonucleotides. A method for the synthesis of the above-mentioned derivatives is also described, which allows the obtainment thereof in high yields and by simple methods. Formula (I), wherein Z is selected from (a) and (b).

专利号:US-9216953-B2
优先权日:2012-11-02
标题 :Chiral 2-arylpropyl-2-sulfinamide and chiral N-2-arylpropyl-2-sulfinylimines and synthesis thereof
发明人：LI GUIGEN; PINDI SURESH
权利人:LI GUIGEN; PINDI SURESH
摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

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合成参考文献

摘要:Wu, X.-F., Science of Synthesis Knowledge Updates, (2014) 1, 255.
摘要:Vallet, A.-L.; Lacôte, E., Science of Synthesis Knowledge Updates, (2014) 4, 33.
摘要:Furuta, T.; Kawabata, T., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 519.
摘要:Yliniemelä-Sipari, S. M.; Pihko, P. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 628.
摘要:Chen, S.; Salo, E. C.; Kerrigan, N. J., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 455.