(E)-3-(1,3-Benzodioxol-5-yl)-3-Chloro-2-Methylprop-2-Enal置于5%-Palladium/activated Carbon 氢气,Sodium Carbonate,三乙胺体系中,用 水 用作溶剂,95.0 °C,600.01 Kpa 条件下,反应 12.0H,以95.6%的收率获得胡椒基丙醛 参考文献: Process For The Preparation Of 3-(3,4-Methylenedioxyphenyl)-2-Methylpropanal[fr] Procede De Preparation De 3-(3,4-Methylenedioxyphenyl)-2-Methylpropanal 标题: Process For The Preparation Of 3-(3,4-Methylenedioxyphenyl)-2-Methylpropanal[fr] Procede De Preparation De 3-(3,4-Methylenedioxyphenyl)-2-Methylpropanal 摘要:制备3-(3,4-亚甲二氧基苯基)-2-甲基丙醛(i)的过程包括以下步骤:A)在0oc至40oc的温度下,将5-丙酰基-1,3-苯并二氧杂环(III)与vilsmeier试剂反应,随后在无极性溶剂中使用碱处理反应混合物,以获得公式(iv)的不饱和氯代醛;B)在有机碱或有机和无机碱混合物的存在下,使用含有pd,Pt,Rh,Ru等金属的支持异相催化剂,在氢气存在下,将在前一步骤中获得的公式(iv)的不饱和氯代醛与氢气反应.
专利号:WO-2004058727-A1 优先权日:2002-12-20 标题 :Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity 发明人:CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA 权利人:BAYER PHARMACEUTICALS CORP; CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA 摘要:This invention relates to substituted 3,5-dihydro-4H-imidazol-4-ones compounds which are useful in the treatment of obesity and obesity-related disorders, and as weight-loss and weight-control agents. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
专利号:US-7501536-B2 优先权日:2005-01-19 标题 :Odorant compounds, synthesis method, and uses of said compounds 发明人:JAUNKY PIOTR; MANE JEAN; SCHROEDER MARTIN 权利人:MANE FILS V 摘要:A compound of general formula (I) with or without the double bond illustrated by the dotted line. In formula (I), X is a CHO, CH2OH, CH2OC(O)R or CH(OR)2 group, and R represents a linear or branched C1-C5 alkyl or alkenyl chain. The synthesis method for the compound, and especially the 6,8-dimethyl-non-7-enal (1) prepared by the hydroformylation of the 5,7-dimethyl-octa-1,6-diene is also disclosed, as well as compositions containing the compounds of formula (I). Due to the odorant properties thereof, the compounds are highly useful in perfumery, especially for cosmetic products and household products.
专利号:WO-2018192923-A1 优先权日:2017-04-18 标题 :Alpha alkylation of aldehyde with a polycyclic olefin 发明人:QUINTAINE JULIE; MACMILLAN DAVID W C 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically to the alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof and wherein R represents a hydrogen atom or C 1-8 linear alkyl group; R 1 , R 2 , R 3 and R 4 represent, when taken separately, independently of each other, a hydrogen atom or a C 1-2 linear alkyl group or a C 3-4 linear or branched alkyl group; or R 2 and R 3 , when taken together, represent a C 4-10 linear, branched or cyclic alkanediyl group and n is 1 or 2.
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:WO-2013053940-A1 优先权日:2011-10-14 标题:Method for the synthesis of 18f-labelled biomolecules
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