CAS: 136-40-3; Phenazopyridine Hydrochloride

该化合物是一种合成化合物,主要用作消化与尿道感染或程序有关的疼痛,烧伤和不适的尿止痛剂,其特点是亮橙色,在施用时可导致尿液吸附类似的气泡.该化合物具有包括氮和芳香环在内的分子配方,有助于其药理特性.青色丙烯丙烯酯在当地对尿道粘液进行作用,提供症状缓解,而不是治疗基本感染.它通常通过口腔施用,在胃肠道中吸食良好.常见副作用包括胃肠紊乱和罕见情况下的过敏反应.由于它对尿色的影响,必须告知病人这一点,以避免尿液中的血液混乱.对肾损伤患者进行警告,建议不长期使用.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号141-86-6 2,6-二氨基吡啶 | CAS号94-78-0 非那吡啶

合成工艺路线路线简述

    2,6-二氨基吡啶,苯胺置于盐酸,Sodium Nitrite体系中,化学反应生成盐酸非那吡啶
    参考文献:Baeyens; Bens; De Moerloose,Pharmazie,1980,Vol. 35,# 2,P. 86-91
    标题:Baeyens; Bens; De Moerloose,Pharmazie,1980,Vol. 35,# 2,P. 86-91

    海关参考信息

    专利信息


    专利号:US-8318427-B2
    优先权日:2005-12-29
    标 题 :Use of acid scavengers for the synthesis of standard length and long-mer nucleic acid arrays
    发明人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU
    权利人:KUIMELIS ROBERT G; MCGALL GLENN H; GOLDBERG MARTIN J; XU GUANGYU; AFFYMETRIX INC
    摘要:Protective groups which may be cleaved with an activatable deprotecting reagents are employed to achieve a highly sensitive, high resolution, combinatorial synthesis of pattern arrays of diverse polymers. In preferred embodiments of the instant invention, the activatable deprotecting reagent is a photoacid generator and the protective groups are DMT for nucleic acids and tBOC for amino acids. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

    专利号:US-6723798-B1
    优先权日:2000-08-28
    标 题:Resins having vinyl ether linker for the solid phase organic synthesis
    发明人:YOO SUNGEUN; GONG YOUNGDAE; SEO JINSOO
    权利人:KOREAN RES INST OF CHEMICAL TE
    摘要:The present invention relates to a resin having a vinyl ether linker and more particularly, to a resin having a vinyl ether linker expressed by formula (I), useful for the synthesis of compounds having hetero atoms such as alcohol, thiol, imidazole, triazole and tetrazole by employing combinatorial chemical synthesis on solid supports.

    专利号:WO-2025122636-A1
    优先权日:2023-12-04
    标题:Method for the synthesis of acrylate derivatives
    发明人:CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN
    权利人:ORTHOBOND CORP
    摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.

    专利号:US-8557979-B2
    优先权日:2004-06-10
    标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
    发明人:CHOI WOO-BAEG; KOWALIK EWA
    权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

    专利号:US-2002127598-A1
    优先权日:2000-03-27
    标题 :Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
    发明人:ZHOU WENQIANG; UPENDRAN SATHYA; IYER RADHAKRISHNAN P
    摘要:The invention provides methods for solution-phase synthesis of nucleotide-based compounds and new libraries of such compounds. Compounds of the invention are useful for a variety of therapeutic applications, including treatment of viral or bacterial infections and associated diseases and disorders.

    专利号:US-10933051-B2
    优先权日:2017-06-09
    标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
    发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.
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    主要参考文献


    1: Attia KA, El-Abasawi NM, Abdel-Azim AH. Experimental design of membrane sensor for selective determination of phenazopyridine hydrochloride based on computational calculations. Mater Sci Eng C Mater Biol Appl. 2016 Apr 1;61:773-81. doi: 10.1016/j.msec.2016.01.016. Epub 2016 Jan 8. Chinese. Review. Review. Review. Update in: Rep Carcinog. 2004;11:III213-4.

    合成参考文献


    参考文献:10.1007/s11064-011-0542-y
    摘要:Tang XQ, Fang HR, Li YJ, Zhou CF, Ren YK, Chen RQ, Wang CY, Hu B. Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion. Neurochem Res. 2011 Nov;36(11):2176–85. doi: 10.1007/s11064-011-0542-y.
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