CAS: 152-47-6; 4-Amino-N-(3-Methoxypyrazin-2-yl)Benzenesulfonamide

上下游产品

CAS号655-78-7 4-acetylamino-N... | CAS号4774-10-1 2-氨基-3-甲氧基吡嗪 | CAS号121-60-8 对乙酰氨基苯磺酰氯

2-氨基-3-甲氧基吡嗪置于sodium Hydroxide体系中,用 吡啶,水 用作溶剂,化学反应 4.0H,反应生成磺胺林
参考文献:Necrosulfonamide Inhibits Necroptosis By Selectively Targeting The Mixed Lineage Kinase Domain-Like Protein
标题:Necrosulfonamide Inhibits Necroptosis By Selectively Targeting The Mixed Lineage Kinase Domain-Like Protein
摘要:通过对20万种化合物进行高通量筛选和随后的结构活性关系(sar)研究,我们确定了硫酰胺(nsa)作为一种有效的小分子抑制剂,用于由tnf-A,Smac模拟剂和z-Vad-Fmk(t/s/z)组合诱导的坏死程序.
Doi:10.1039/c3Md00278K

专利信息

专利号:US-2023119068-A1
优先权日:2020-02-13
标题:Methods for rapid synthesis of pyranoanthocyanins
发明人：ZHU XIAOYI; STRAATHOF NICOLE; MIYAGUSUKU-CRUZADO GONZALO; GIUSTI M MONICA; CANO ISRAEL GARCIA; JIMENEZ-FLORES RAFAEL
权利人:OHIO STATE INNOVATION FOUNDATION
摘要:The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.

专利号:US-10005807-B2
优先权日:2013-04-12
标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
发明人：CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:US-8497098-B2
优先权日:2004-07-15
标题 :Biochemical synthesis of 1,4-butanediamine
发明人：EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G
权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV
摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.

专利号:WO-2014167537-A1
优先权日:2013-04-12
标题:Synthesis of sialylated/fucosylated oligosaccharides
发明人：KHANZHIN NIKOLAY; CHASSAGNE PIERRE; HEDEROS MARKUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10, preferably 2 or 3, R 1 is selected from sialyl moiety, -SO 3 H and -CH(R 5 )-COOH wherein R 5 is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that one but only one of R 3 and R 4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:US-9102966-B2
优先权日:2010-07-16
标 题:Synthesis of sialooligosaccharide derivatives
发明人：SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS
权利人:SCHROVEN ANDREAS; CHAMPION ELISE; DEKANY GYULA; RÖHRIG CHRISTOPH; VRASIDAS IOANNIS; FIGUEROA PÉREZ IGNACIO; HEDEROS MARKUS; BOUTET JULIEN; Ã?GOSTON Ã?GNES; KOVÃ?CS-PÉNZES PIROSKA; Horváth Ferenc; RISINGER CHRISTIAN; PIPA GERGELY; DEMKÓ SÃ?NDOR; KRÖGER LARS; GLYCOM AS
摘要:The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X 1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R 1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

专利号:US-2014228554-A1
优先权日:2011-03-18
标 题:Synthesis of new fucose-containing carbohydrate derivatives
发明人：CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY
权利人:GLYCOM AS; GLYCOM AS
摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.