专利号:US-8809526-B2 优先权日:2010-07-19 标题 :Synthesis of cyclopentaquinazolines 发明人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT 权利人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT; ONYX PHARMA INC 摘要:A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).
专利号:US-8729277-B2 优先权日:2009-04-06 标 题:Processes for the synthesis of gamma nitrocarbonyl and gamma dicarbonyl compounds and their pyrrole derivatives 发明人:YANG HU; BARALT EDUARDO J 权利人:YANG HU; BARALT EDUARDO J; CHEVRON PHILLIPS CHEMICAL CO 摘要:The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.
专利号:US-2010075055-A1 优先权日:2008-09-04 标题:HYDROTHERMAL SYNTHESIS OF ALPHA ALUMINA (a-AL2O3)-BASED FILMS AND COATINGS 发明人:SUCHANEK WOJCIECH L 权利人:SAWYER TECHNICAL MATERIALS LLC 摘要:A process to deposit an Alpha Alumina (α-Al 2 O 3 ) crystalline coating on a substrate surface, wherein the process includes hydrothermal synthesis of the α-Al 2 O 3 crystalline coating.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:WO-2017072790-A1 优先权日:2015-10-26 标 题 :An improved process for synthesis of ticagrelor 发明人:RAO RAMAKRISHNA; NANDIPATI RAMADEVI; SHEWALKAR MUKESH PADMAKAR; BOGIREDDY VEERABHADRA REDDY 权利人:AVRA LABORATORIES PVT LTD 摘要:The present invention discloses an improved and cost effective process for preparation of Ticagrelor in good yield and purity. The invention further discloses novel Polymorphic Form of Ticagrelor and its process for preparation thereof.
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合成参考文献
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