CAS: 22245-83-6; 3-(Trifluoromethyl)Pyridin-2-Ol

相似化合物

1806766-03-9 1214342-70-7 887707-23-5

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CAS号142-08-5 2-羟基吡啶 | CAS号2314-97-8 三氟碘甲烷 | CAS号65753-47-1 2-氯-3-(三氟甲基)吡啶 | CAS号887707-23-5 2-羟基-5-碘-3-(三氟甲基)吡啶 | CAS号99368-66-8 2-羟基-3-三氟甲基-5-硝基吡啶 | CAS号887707-25-7 2-氯-5-碘-3-三氟甲基吡啶 | CAS号76041-79-7 5-溴-2-羟基-3-(三氟甲基)吡啶 | CAS号104040-74-6 2-巯基-3-三氟甲基吡啶 | CAS号887707-27-9 5-碘-2-甲氧基-3-(三氟甲基)吡啶 | CAS号887707-29-1 6-甲氧基-5-(三氟甲基)烟腈 | CAS号887707-33-7 5-(CHLOROMETHYL...

2-氯-3-三氟甲基吡啶置于溶剂黄146体系中,用 水 用作溶剂,化学反应 168.0H,以93%的收率获得2-羟基-3-三氟甲基吡啶
参考文献:Substituted Diazaspiroalkanes As Androgen Receptor Modulators
标题:Substituted Diazaspiroalkanes As Androgen Receptor Modulators
摘要:这项发明提供了formula Ii的化合物:其中a,B,Het,R1,R2和r3如本文所述.这些化合物是雄激素受体调节剂,用于治疗雄激素受体相关疾病.

专利信息

专利号:US-9926291-B2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins
发明人：OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG
权利人:SLOAN KETTERING INST CANCER RES
摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

专利号:US-2023046065-A1
优先权日:2019-11-25
标题 :MERGING C(sp3)-H ACTIVATION WITH DNA-ENCODING
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:Palladium-catalyzed C(sp3)—H arylation of aliphatic carboxylic acids, amides and ketones with BNA-encoded aryl iodides in water is disclosed, Furthermore, sequential C—H arylation chemistry enabled the on-DNA synthesis of structurally-diverse scaffolds containing enriched C(sp3) character, chiral centers, cyclopropane, cyclobutane, and heterocycles. That new chemistry permits preparation of a DNA—encoded library (BEL) technology that can dramatically expedite hit identification in drug discovery owing to its ability to perform protein affinity selection with millions or billions of molecules in a single experiment. The sequential functionalization of multiple C—H bonds provides an unique avenue for creating diversity and complexity from simple starting materials. The use of water as solvent, the presence of DMA, and the extremely low concentration of DMA-encoded coupling partners (0.001 M) have previously hampered the development DMA-encoded C(sp3)—H activation reactions, but many of those hurdles have now been overcome.

专利号:WO-2008119015-A2
优先权日:2007-03-27
标 题 :Synthesis of thiohydantoins

专利号:US-8987452-B2
优先权日:2007-03-27
标 题:Synthesis of thiohydantoins

专利号:US-2010190991-A1
优先权日:2007-03-27
标题 :Synthesis of thiohydantoins

专利号:US-9512103-B2
优先权日:2007-03-27
标题:Synthesis of thiohydantoins