CAS: 22502-03-0; 2-Methoxyethyl 3-Oxobutanoate

相似化合物

33736-01-5 22502-03-0 5459-04-1

上下游产品

CAS号674-82-8 双乙烯酮 | CAS号109-86-4 乙二醇甲醚 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号85920-63-4 5-(1-羟基亚乙基)-2,2... | CAS号39562-22-6 3-硝基苯叉基乙酰乙酸甲氧乙酯 | CAS号66085-59-4 尼莫地平 | CAS号21881-78-7 1,4-二氢-2,6-二甲基-... | CAS号74936-76-8 5-(2-methoxyeth... | CAS号50899-10-0 4-胺基巴豆酸(-2-甲氧基)乙酯

双乙烯酮,乙二醇甲醚置于三乙胺体系中,用 氯仿 用作溶剂,化学反应 10.0H,以87.6%的收率获得乙酰乙酸甲氧乙酯
参考文献:新型的2-氨基-1,4-二氢吡啶类钙拮抗剂.二.在3-和/或5-位具有n,N-二烷基氨基烷氧基羰基的2-氨基-1,4-二氢吡啶衍生物的合成和降压作用.
标题:新型的2-氨基-1,4-二氢吡啶类钙拮抗剂.二.在3-和/或5-位具有n,N-二烷基氨基烷氧基羰基的2-氨基-1,4-二氢吡啶衍生物的合成和降压作用.
摘要:合成了在3和/或5位上含有n,N,-二烷基氨基烷氧基羰基的新型2-氨基-1,4-二氢吡啶衍生物i,并在自发性高血压大鼠中评估了其降压作用.当叔氨基被引入1,4-二氢吡啶环的3-和/或5-酯侧链时,观测到抗高血压作用的持续时间显着延长.特别地,在3位含有环氨基的化合物比具有无环氨基的化合物显示出更高的效力.化学修饰研究表明,在3和5位的1,4-二氢吡啶的两个酯侧链可能以与抗高血压活性有关的不同方式起作用.
Doi:10.1248/cpb.43.797

专利信息

专利号:US-9908893-B2
优先权日:2013-06-11
标题 :Thieno [2,3-b] pyridines as multidrug resistance modulators
发明人：KALVINS IVARS; KRAUZE AIVARS; GRINBERGA SIGNE; KRASNOVA LAURA; JASCHENKO ELINA; DOMRACHEVA ILONA; ADLERE ILZE; ANDZANS ZIGMARS; SHESTAKOVA IRINA; DUBURS GUNARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The thieno[2,3-b]pyridines of general formula (I), n nwhereinn nR 1 is Me, C 6 H 5 , 3,4,5-(OMe) 3 C 6 H 2 , NH 2 ;n nR 2 is H, CN, COMe, COOC 1-4 alkyl, COOC 2 H 4 OMe, COOC 2 H 4 OPr(n);n nR 3 is C 6 H 4 R 6 , 3,4-OCH 2 O—C 6 H 3 ; 2-furanyl;n R 6 is 4-Cl, 4-NO 2 , 4-N(C 1-4 alkyl) 2 , 3-(C 1-4 alkyloxy), 4-(C 1-4 alkyloxy), 3,4-(C 1-4 alkyloxy) 2 , 3,4,5-(C 1-4 alkyloxy) 3 ;n nR 4 is NH 2 , NHCOMe;n nR 5 is CN, COMe, COC 6 H 4 R 7 ; CO-(2-naphthyl);n R 7 is H, 4-F, 4-Cl, 3-OMe, 4-OMe, 2,4-(OMe) 2 , 3,4,5-(OMe) 3 n nas multidrug resistance modulators to increase the effectiveness of chemotherapy in cancer treatment.

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