专利号:US-4267355-A 优先权日:1975-11-05 标 题 :Production of herbicidally-active derivatives of alanine 发明人:SCOTT RICHARD M; ARMITAGE GEOFFREY D 权利人:SHELL OIL CO 摘要:Stereospecific synthesis of ##STR1## (R-configuration at C 2 ) by reaction of ##STR2## (S-configuration at C 2 ) with ##STR3## at elevated temperature in the presence of a base, e.g., R-(-)-(2-(N-benzoyl-3-chloro-4-fluoroanilino)propionic acid isopropylester) from S-(-)-isopropyl lactate mesylate and 3-chloro-4-fluoroaniline followed by benzoylation. The compounds are very active herbicides against broad-leafed weeds (R=H) or wild oats (R=(thio)benzoyl).
专利号:US-7365203-B2 优先权日:2003-09-15 标题:Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile 发明人:DAIGNEAULT SYLVAIN; MICHALAK RONALD STANLEY; BERNATCHEZ MICHEL 权利人:WYETH CORP 摘要:The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
专利号:EP-0332033-A2 优先权日:1988-03-11 标 题:N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives 发明人:SCHRIEWER MICHAEL DR; PETERSEN UWE DR; GROHE KLAUS DR; KREBS ANDREAS DR 权利人:BAYER AG 摘要:N-Cyclopropylanilines of the formula (IV) in which R<1>, X<1>, X<2>, X<3>, A, Z and R<2> have the meaning given in the description, which are suitable for the preparation of 4-quinolone- 3-carboxylic acids, and processes for the preparation of quinolone- carboxylic acid derivatives using N-cyclopropylanilines.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2008161575-A1 优先权日:2003-09-15 标题:Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile
参考标题:Synthesis Of Newer 1,2,3-Triazole Linked Chalcone And Flavone Hybrid Compounds And Evaluation Of Their Antimicrobial And Cytotoxic Activities 作者:Rama Kant,Dharmendra Kumar,Drishti Agarwal,Rinkoo Devi Gupta,Ragini Tilak,Satish Kumar Awasthi,Alka Agarwal |发布日期:2016.5 摘要:The Antiplasmodial And Cytotoxic Activities Of These Compounds Were Also Evaluated Against Human Malaria Parasite Plasmodium Falciparum Strain 3D7 And Human Hepato-Cellular Carcinoma Cells (Huh-7), Respectively. Compounds 10A, 10C, 10D, 12C And 14E Showed Promising Antibacterial Activity While Compounds 10E, 11D, 11E, 12C, 13A, 13B, 13E, 14A And 14D Showed Good Antifungal Activity As Compared To The Corresponding
合成参考文献
参考文献:10.1107/s1600536811012608 摘要:Singh MK, Agarwal A, Awasthi SK. Benzyl N-(3-chloro-4-fluoro-phen-yl)carbamate. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1137.