CAS: 40473-01-6; 2-Bromo-5-Chloropyridine

相似化合物

14482-51-0 1033203-42-7 96424-68-9

上下游产品

CAS号1072-98-6 2-氨基-5-氯吡啶 | CAS号16110-09-1 2,5-二氯吡啶 | CAS号4214-79-3 5-氯-2-吡啶醇 | CAS号1061357-88-7 2-溴-5-氯-4-碘吡啶 | CAS号605681-01-4 2-溴甲基-5-氯吡啶 | CAS号349-94-0 5-氯-2-三氟甲基吡啶 | CAS号94952-46-2 1-(5-氯吡啶-2-基)乙酮 | CAS号87394-65-8 1-(5-氯-2-吡啶)哌嗪 | CAS号31181-89-2 5-氯吡啶-2-甲醛 | CAS号86873-60-1 5-氯吡啶-2-羧酸 | CAS号652148-91-9 5-氯吡啶-2-硼酸 | CAS号652148-93-1 5-氯吡啶-2-硼酸频哪醇酯 | CAS号58254-76-5 5-氯-2-苯基吡啶

2,5-二氯吡啶置于三甲基溴硅烷体系中,用 Various Solvent(S) 作为反应溶剂,以67%的收率获得产物2-溴-5-氯吡啶
参考文献:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
标题:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
摘要:用溴三甲基硅烷加热将 2-氯吡啶转化为 2-溴吡啶,将 2-氯-6-甲基吡啶转化为 2-溴-6-甲基吡啶.2-氯吡啶和2-溴吡啶都得到相应的碘化合物.当用原位反应生成的碘三甲基硅烷处理时.尽管 3-和 4-氯吡啶是完全惰性的,但 2,4-二氯吡啶在 2-和 4-位同时进行卤素/卤素交换.卤素置换仅在 2-位与 2,3-二氯吡啶和 2,5-二氯吡啶发生.与作为发生卤素交换的先决条件的 N-三甲基甲硅烷基吡啶鎓盐的中间体一致,2-氟吡啶和 2-氟-6-甲基吡啶和任何 2,6-二卤代吡啶都不发生反应.最后,溴/氯和碘/氯取代也可以用 2-或 4-氯喹啉,1-氯异喹啉,2-氯嘧啶,氯吡嗪和 2,3-二氯喹喔啉作为底物来完成.[在 Scifinder (R) 上]
DOI:10.1002/1099-0690(200212)2002:24<4181::Aid-Ejoc4181>3.0.Co;2-M

专利信息

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2003135046-A1
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds

专利号:EP-4630405-A1
优先权日:2022-12-06
标题 :Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels

专利号:WO-2009073246-A1
优先权日:2007-12-06
标 题 :Method for the synthesis of iridium (iii) complexes with sterically demanding ligands