专利号:US-2013133483-A1 优先权日:2010-03-08 标题 :Synthesis of Nanoparticles Using Reducing Gases 发明人:YANG HONG; WU JIANBO; SHI MIAO; GROSS ADAM 权利人:YANG HONG; WU JIANBO; SHI MIAO; GROSS ADAM; UNIV ROCHESTER 摘要:Selective gas-reducing methods for making shape-defined metal-based nanoparticles. By avoiding the use of solid or liquid reducing reagents, the gas reducing reagent can be used to make shape well-defined metal- and metal alloy-based nanoparticles without producing contaminates in solution. Therefore, the post-synthesis process including surface treatment become simple or unnecessary. Weak capping reagents can be used for preventing nanoparticles from aggregation, which makes the further removing the capping reagents easier. The selective gas-reducing technique represents a new concept for shape control of nanoparticles, which is based on the concepts of tuning the reducing rate of the different facets. This technique can be used to produce morphology-controlled nanoparticles from nanometer- to submicron- to micron-sized scale. The Pt-based nanoparticles show improved catalytic properties (e.g., activity and durability).
专利号:US-6924375-B2 优先权日:2003-09-03 标题:Facile synthesis of 1,9-diacyldipyrromethanes 发明人:LINDSEY JONATHAN S; TAMARU SHUN-ICHI; YU LIANHE 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides a method of making a metal complex. The method comprises the steps of: (a) acylating a dipyrromethane or a 1-monoacyldipyrromethane to form a mixed reaction product comprising a 1,9-diacyidipyrromethane; (b) combining the reaction product with a compound of the formula R 2 MX 2 in the presence of a base, where R is alkyl or aryl, M is Sn, Si, Ge, or Pb (preferably Sn), and X is halo, OAc, acac, or OTf, to form a product comprising a metal complex of the formula DMR 2 in the mixed reaction product, wherein D is a 1,9-diacyldipyrromethane; and then (c) separating the metal complex from the mixed reaction product. The method may be utilized for the convenient synthesis and separation of 1,9-diacyldipyrromethanes. Metal complex intermediates useful in such methods are also described.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-5856107-A 优先权日:1997-02-04 标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein 发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
专利号:US-7390801-B2 优先权日:1996-12-23 标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J 权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
[参考文献]: Magorzata Sleszyńska, Et Al. Novel Bradykinin Analogues Modified In The N-Terminal Part Of The Molecule With A Variety Of Acyl Substituents. Int J Pept Res Ther. 2012 Jun;18(2):117-124.
合成参考文献
摘要:Bietti, M.; Dénès, F., Science of Synthesis, (2021) , 561. 摘要:Vicens, L.; Palone, A.; Costas, M., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 483.