CAS: 75-19-4; Cyclopropane

上下游产品

cyclobutanone methylene diethyl ether ethene3-chloro-2-methyl-1-phenylpropan-1-one 4-chloro-1-phenylbutan-1-one 3-propyl, 1-methylcyclohexane 1-Propyl acetate

Cyclopropene置于氢气体系中,化学反应生成 环丙烷
参考文献:还原/加氢热的计算精度:在某些小型环形系统中的应用
标题:还原/加氢热的计算精度:在某些小型环形系统中的应用
摘要:在hf,B3Lyp,M06,Mp2,G3,G4,Cbs-Qb3,Cbs-Apno和w1Bd浓度下,已计算出羰基化合物还原和烯烃氢化的焓,在前四种方法中,使用各种基础设置,直到aug-Cc-Pvtz.将结果与可用的实验数据进行比较,发现复合方法通常比其他方法更令人满意.通常需要大的基础集才能重现实验.还研究了某些c-c键氢解反应,包括双环烷烃和螺旋桨的氢解反应.另外,研究了显着应变的双环[2.2.0] Hex(1,4)烯的二聚作用.计算形成五环丙烷的反应具有δh=-57Kcal / Mol,并且丙炔的裂解得到二烯的δh=-71Kcal / Mol.估计了这些化合物的应变能.
DOI:10.1021/jo302118B

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2016031800-A1
优先权日:2013-03-14
标 题:Synthesis of chiral kynurenine compounds and intermediates
发明人：TRETYAKOV ALEXANDER; DROUET KEITH E; SANDERS WILLIAM
权利人:VISTAGEN THERAPEUTICS INC
摘要:Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine.

专利号:US-8138346-B2
优先权日:2006-08-16
标题 :Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. n nThe substituents R, R 5 , R 6 , R 7 , R 8 and R 9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.

专利号:US-2003162992-A1
优先权日:2001-12-14
标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides
发明人：WATANABE KYOICHI A; DU JINFA
摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.

专利号:US-9221829-B2
优先权日:2011-09-14
标题:Synthesis of triazolopyrimidine compounds
发明人：MARAS NENED; ZUPANCIC BORUT
权利人:MARAS NENED; ZUPANCIC BORUT; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).

专利号:EP-2644590-A1
优先权日:2012-03-30
标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.