CAS: 103438-88-6; 2-Fluoro-3-Methoxybenzaldehyde

相似化合物

137654-20-7 958991-48-5 198203-94-0

上下游产品

1-fluoro-2-methoxybenzene N,N-dimethyl-formamide 2-amino-3-methoxybenzaldehyde dimethyl acetal 2-fluoro-3,N-dimethoxy-N-methyl-benzamide 2-fluoro-3-hydroxybenzaldehyde 2-fluoro-3-methoxybenzoic acid 5-carbonitrile-4-chloro-6-(2-fluoro-3-methoxyphenyl)-2-(methylthio)pyrimidine d]pyrimidine-6-carboxylic acid5-amino-4-(2-fluoro-3-methoxy-phenyl)-2-methylsulfanyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

2-氟-3-甲氧基苯甲酸置于benzotriazol-1-Yloxyl-Tris-(Pyrrolidino)-Phosphonium Hexafluorophosphate,二异丁基氢化铝,三乙胺体系中,用 四氢呋喃,二氯甲烷,甲苯 用作溶剂,化学反应 6.67H,反应生成2-氟-3-甲氧基苯甲醛
参考文献: 3-Aryloxy/thio-3-Substituted Propanamines And Their Use In Inhibiting Serotonin And Norephinephrine Reuptake[fr] Composes Pharmaceutiques
标题: 3-Aryloxy/thio-3-Substituted Propanamines And Their Use In Inhibiting Serotonin And Norephinephrine Reuptake[fr] Composes Pharmaceutiques
摘要:提供一种具有以下结构的化合物(i):其中a从-O-和-S-中选择;X从c2-C8烷基,C2-C8烯基,C3-C8环烷基和c4-C8环烷基烷基中选择,每种基团可能分别被选自卤素,C1-C4烷基,C1-C4烷氧基,C1-C4烷基-S(O)N-(其中n为0,1或2),-Cf3,-Cn和-Conh2的最多3个取代基所取代;Y从苯基,萘基,二氢苯并噻吩基,苯并噻唑基,苯并异噻唑基,喹啉基,异喹啉基,萘啉基,噻吩吡啉基,茚基,1,3-苯并二氧杂环戊基,苯并噻吩基,吲哚基和苯并呋喃基中选择,每种基团可能分别被选自卤素,C1-C4烷基,C1-C4烷氧基,C1-C4烷基-S(O)N-(其中n为0,1或2),硝基,乙酰基,-Cf3,-Scf3和氰基的最多4个或在可能的情况下5个取代基所取代;当y为吲哚基时,它可以被选自c1-C4烷基的n-取代基取代或进一步取代;Z从h,Or3或f中选择,其中r3从h,C1-C6烷基和苯基c1-C6烷基中选择;R1和r2分别独立地为h或c1-C4烷基;但是,当z为h时,Y可能不是可选择地取代的苯基或可选择地取代的萘基.

专利信息

专利号:EP-3070087-B1
优先权日:2011-08-05
标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:EP-3070087-A1
优先权日:2011-08-05
标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:WO-2015088565-A1
优先权日:2013-12-13
标题:P2x4 receptor modulating compounds and methods of use thereof
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.

专利号:ES-2733096-T3
优先权日:2011-08-05
标题:Intermediaries for the synthesis of cyclic P1 linkers as XIA factor inhibitors

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.